High-biologically effective dose palliative radiotherapy for a tumor thrombus might improve the long-term prognosis of hepatocellular carcinoma: a retrospective study

Autor: Yu-yin Le, Junxin Wu, Jinluan Li, Jun-yan He, Xiangquan Kong, Ya-ping Dong, Kaixin Du, Qingqin Peng
Rok vydání: 2017
Předmět:
lcsh:Medical physics. Medical radiology. Nuclear medicine
Oncology
Adult
Male
medicine.medical_specialty
Carcinoma
Hepatocellular
Hepatocellular carcinoma
lcsh:R895-920
medicine.medical_treatment
lcsh:RC254-282
Effective dose (radiation)
Biologically effective dose
03 medical and health sciences
0302 clinical medicine
Tumor thrombus
Palliative radiotherapy
Internal medicine
medicine
Humans
Radiology
Nuclear Medicine and imaging
Overall survival
Aged
Retrospective Studies
Univariate analysis
Prognostic factor
Performance status
business.industry
Research
Liver Neoplasms
Palliative Care
Retrospective cohort study
Radiotherapy Dosage
Thrombosis
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Prognosis
Radiation therapy
Survival Rate
030220 oncology & carcinogenesis
030211 gastroenterology & hepatology
Female
business
Follow-Up Studies
Zdroj: Radiation Oncology (London, England)
Radiation Oncology, Vol 12, Iss 1, Pp 1-9 (2017)
ISSN: 1748-717X
Popis: Background This study aimed to highlight the type of tumor thrombus and identify the prognostic factors influencing the long-term survival outcomes in patients with hepatocellular carcinoma (HCC) having a tumor thrombus. A tumor thrombus in HCC is associated with poor prognosis. Methods Eighty patients diagnosed with HCC having a tumor thrombus between May 2006 and April 2014 were enrolled in this study. Age, gender, clinical characteristics, laboratory findings, Child-Pugh classification, performance status (ECOG), types of tumor thrombi, radiotherapy method, biologically effective dose (BED), and primary treatment method were analyzed to identify the prognostic factors associated with the overall survival (OS) rates. Statistical analyses were performed using SPSS version 19.0. Results The median follow-up duration was 24 months (range 6–90). The 1-, 3-, and 5-year OS rates of the patients were 77.6%, 37.6%, and 18.8%, respectively. On univariate analysis, gender, radiotherapy method, BED, types of tumor thrombi, Child-Pugh classification, ECOG, and total bilirubin were associated with OS (P
Databáze: OpenAIRE
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