Improvement of Left Ventricular Remodelling by Inhibition of NF-κB in a Rat Model of Myocardial Infarction
| Autor: | Jin-lan Jin, Rong-gui Lv, Xi-hong Liu, Lexin Wang, Jian Guo, Yan-wen Liang, Jian-rui Wei |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Pulmonary and Respiratory Medicine medicine.medical_specialty Myocardial Infarction 030204 cardiovascular system & hematology Anterior Descending Coronary Artery Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pyrrolidine dithiocarbamate Internal medicine medicine Animals Myocardial infarction Ventricular remodeling Ejection fraction Ventricular Remodeling business.industry NF-kappa B NF-κB NFKB1 medicine.disease Rats Disease Models Animal 030104 developmental biology chemistry cardiovascular system Cardiology Cardiology and Cardiovascular Medicine business Ligation Signal Transduction |
| Zdroj: | Heart, Lung and Circulation. 25:1007-1012 |
| ISSN: | 1443-9506 |
| Popis: | To investigate the effects of inhibition of NF-κB activation on left ventricular (LV) remodelling in a rat model of myocardial infarction (MI).The acute MI model was established by ligation of left anterior descending coronary artery. Pyrrolidine dithiocarbamate (PDTC) (20mg/kg, Qd) was administered intraperitoneally to inhibit NF-κB activation. Eight weeks later, the cardiac structure and LV ejection fraction were assessed with echocardiography. The rat body, heart, and LV weights were measured to calculate LV mass indices. Activation of NF-κB in non-infarcted myocardium was detected by a TransAM NF-κB p65 Transcription Factor Assay Kit. Cardiac collagen volume fraction was evaluated by Masson staining.Eight weeks after the MI model was established, the LV posterior wall thickness in PDTC and MI group was 1.75±0.07mm and 1.85±0.07mm respectively (p0.05). The LV mass index in the PDTC group (2.53±0.09) was lower than in the MI group (2.65±0.08, p0.05). The LVEF in the PDTC group (63.89%±4.21%) was higher than in the MI group (42.73%±8.94%, p0.05). The interstitial collagen deposition in the non-infarcted myocardium in the PDTC group was less than in the MI group (7.25%±1.88% vs. 10.09%±2.19%, p0.05).Inhibition of activation of NF-κB may result in improvement of myocardial remodelling after myocardial infarction, which is possibly attributable to reduced collagen deposition in non-infarcted areas. |
| Databáze: | OpenAIRE |
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