Exposure to biomass smoke, cigarettes, and alcohol modifies the association between tumour necrosis factor (–308G/A, –238G/A) polymorphisms and tuberculosis in Mexican carriers
| Autor: | Luz María Torres Espíndola, Citlaltepetl Salinas Lara, Manuel de Jesús Castillejos López, Nelly Patiño, Martha Lilia Tena Suck, Rafael Velazquez Cruz, Jorge L Guerrero Camacho, Jesús D Rembao Bojórquez, Israel Torres Ramírez de Arellano, Aurelio Jara Prado |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Tuberculosis Population lcsh:Medicine Alcohol cigarette Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine 030212 general & internal medicine Allele education risk education.field_of_study business.industry alcohol Haplotype lcsh:R Risk factors for tuberculosis General Medicine Odds ratio medicine.disease protection Confidence interval Basic Research chemistry tuberculosis biomass smoke business polymorphisms |
| Zdroj: | Archives of Medical Science, Vol 16, Iss 3, Pp 672-681 (2020) Archives of Medical Science : AMS |
| ISSN: | 1896-9151 1734-1922 |
| Popis: | Introduction Exposure to biomass smoke, cigarettes, alcohol, and the impairment of immunoregulation are considered to be risk factors for tuberculosis. Tumour necrosis factor (TNF) -308G/A and -238G/A gene polymorphisms have been associated with tuberculosis. However, the results remain inconsistent. The aim of this study was to determine the association between TNF polymorphisms and tuberculosis in the presence of biomass smoke, cigarettes, and alcohol in a Mexican population. Material and methods TNF polymorphisms were determined in 118 tuberculosis patients and 223 controls. We performed a univariate, bivariate, stratified analysis. Odds ratios, confidence intervals, and p-values were calculated. Results Occupational biomass smoke exposure was associated with tuberculosis between the patients and controls (OR = 1.70, 95% CI: 1.08-2.70, p = 0.02). We also found an association of the -308A allele carriers between the patients and controls without exposure to occupational (p = 0.04, OR = 0.16, 95% CI: 0.01-0.92) and in-home (p = 0.02, OR = 0.14, 95% CI: 0.01-0.81) biomass smoke, as well as an association with alcohol (p = 0.01, OR = 0.24, 95% CI: 0.05-0.75). The haplotype analysis revealed an association of the -308A/-238G haplotype between patients and nonconsanguineous controls without exposure to occupational (p = 0.02, OR = 0.12, 95% CI: 0.01-0.99) and in-home (p = 0.01, OR = 0.1, 95% CI: 0.01-0.9) biomass smoke, cigarette use (p = 0.04, OR = 0.28, 95% CI: 0.08-0.98), and alcohol (p = 0.02, OR = 0.22, 95% CI: 0.05-0.88) intake. Conclusions The TNF -308A allele and the -308A/-238G haplotype are associated with tuberculosis, as are exposure to biomass smoke, cigarettes, and alcohol. No association for the -238G/A polymorphism was found. Our results provide insight into a possible protective role of TNF polymorphisms in tuberculosis in our population. |
| Databáze: | OpenAIRE |
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