Validation of the echocardiographic assessment of epicardial adipose tissue thickness at the Rindfleisch fold for the prediction of coronary artery disease
| Autor: | Maria Gabriella Grimaldi, Dario Bruzzese, Patrizio Lancellotti, Stefania Paolillo, Emilio Attena, Dario Leosco, Alessandra Scatteia, Santo Dellegrottaglie, Pasquale Campana, A. Caruso, Vincenzo Russo, Laura Petraglia, Maddalena Conte, Annarita Iavazzo, Fabrizio Vincenzo Grieco, Pasquale Perrone Filardi, Emanuele Pilato, Valentina Parisi, Roberto Formisano |
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| Přispěvatelé: | Parisi, V., Petraglia, L., Formisano, R., Caruso, A., Grimaldi, M. G., Bruzzese, D., Grieco, F. V., Conte, M., Paolillo, S., Scatteia, A., Dellegrottaglie, S., Iavazzo, A., Campana, P., Pilato, E., Lancellotti, P., Russo, V., Attena, E., Filardi, P. P., Leosco, D., Parisi, Valentina, Petraglia, Laura, Formisano, Roberto, Caruso, Aurelio, Grimaldi, Maria Gabriella, Bruzzese, Dario, Grieco, Fabrizio Vincenzo, Conte, Maddalena, Paolillo, Stefania, Scatteia, Alessandra, Dellegrottaglie, Santo, Iavazzo, Annarita, Campana, Pasquale, Pilato, Emanuele, Lancellotti, Patrizio, Russo, Vincenzo, Attena, Emilio, Filardi, Pasquale Perrone, Leosco, Dario |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Coronary angiography
Adult Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Medicine (miscellaneous) Reproducibility of Result 030209 endocrinology & metabolism Predictive Value of Test Coronary Artery Disease 030204 cardiovascular system & hematology Coronary Angiography Coronary artery disease 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Internal medicine Epicardial adipose tissue medicine Humans Aged Observer Variation Reproducibility Nutrition and Dietetics business.industry digestive oral and skin physiology Reproducibility of Results Middle Aged medicine.disease Predictive value Magnetic Resonance Imaging Trustworthiness Adipose Tissue Echocardiography Risk stratification Cardiology Female Cardiology and Cardiovascular Medicine business Cardiac magnetic resonance Pericardium Human |
| Popis: | Background and Aim: Echocardiography is a promising technique for the assessment of epicardial adipose tissue (EAT). Increased EAT thickness is associated with different cardiac diseases, including; coronary artery disease (CAD). Since several different echocardiographic approaches have been proposed to measure EAT, the identification of a standardized method is needed. We propose the assessment of EAT maximal thickness at the Rindfleisch fold, the reproducibility of this measurement and its correlation with EAT thickness and volume assessed at cardiac magnetic resonance (CMR). Finally, we will test the predictive role of this measurement on the presence of significant CAD. Methods and Results: In 1061 patients undergoing echocardiography, EAT thickness was measured at the level of the Rindfleisch fold. In 70 patients, we tested the relationship between echo-EAT thickness and EAT thickness and volume assessed at CMR. In 499 patients with suspected CAD, undergoing coronary artery angiography, we tested the predictive value of EAT on the presence of significant CAD. Echo-EAT thickness measurements had an excellent reliability as indicated by the inter-observer (ICC:0.97; 95% C.I. 0.96 to 0.98) and intra-observer (ICC:0.99; 95% C.I. 0.98 to 0.99) reliability rates. Echo-EAT thickness significantly correlated with CMR-EAT thickness and volume (p < 0.001). An EAT thickness value >10 mm discriminated patients with significant CAD at coronary angiography (p < 0.001). At multivariable analysis, including demographic data and cardiovascular risk factors, EAT thickness was an independent predictor of significant CAD and showed an additive predictive value over common atherosclerotic risk factors. Conclusions: Echocardiographic assessment of EAT thickness at the level of the Rindfleisch fold represents a simple and trustworthy method. An increased EAT thickness shows an additive predictive value on CAD over common atherosclerotic risk factors, thus suggesting its potential clinical use for CAD risk stratification. |
| Databáze: | OpenAIRE |
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