The Role of the Histocompatibility-2-Linked Ss-Slp Region in the Control of Mouse Complement
| Autor: | Jana Capková, Peter Demant, Bela Vorácová, Eva Hinzová |
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| Jazyk: | angličtina |
| Rok vydání: | 1973 |
| Předmět: |
Genetics
Recombination Genetic Multidisciplinary Genotype Genetic Linkage Immune Sera Haplotype Complement Fixation Tests Congenic Mice Inbred Strains Complement System Proteins Biology Molecular biology Histocompatibility Complement system Mice Genes Genetic linkage Chromium Isotopes Animals Allele Gene Biological Sciences: Genetics |
| Popis: | The Ss-Slp region of the mouse genome is located between the two loci, H-2K and H-2D , of the major histocompatibility system. It controls the level of a serologically detectable serum globulin, the Ss protein, and its allotypic forms, Slp a and Slp o . Evidence is presented that the Ss-Slp region is involved in control of the complement system. Mice of congenic resistant strains differing only at the H-2 gene complex show differences in complement levels. A comparison of H-2 recombinants demonstrated that complement level correlates with the Ss-Slp genotype and not with the H-2K, H-2D , or Ir genotypes. Among the 13 congenic strains tested, those with the Ss h Slp a allele had higher complement levels than those with the Ss h Slp o or Ss l Slp o alleles. Mice with recombinant H-2 haplotypes had complement levels similar to those of the parental strain that provided the Ss-Slp segment. It was also shown that anti-Ss serum inhibits complement activity of mouse serum in vitro . |
| Databáze: | OpenAIRE |
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