Lipopolysaccharide-induced functional and structural injury of the mitochondria in the nigrostriatal pathway
| Autor: | Randy L. Hunter, Guoying Bing, Uttam Ojha, Sunil Bhurtel, Dong-Young Choi |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Lipopolysaccharides Male Mitochondrial Diseases Tyrosine 3-Monooxygenase Nigrostriatal pathway Substantia nigra Cell Count Striatum Mitochondrion Biology medicine.disease_cause Mitochondrial Proteins Rats Sprague-Dawley Striatonigral Degeneration 03 medical and health sciences 0302 clinical medicine medicine Animals Neuroinflammation General Neuroscience Dopaminergic Neurodegeneration General Medicine medicine.disease Cell biology Mitochondria Rats Substantia Nigra Disease Models Animal Microscopy Electron Oxidative Stress 030104 developmental biology medicine.anatomical_structure nervous system Neuroscience 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Neuroscience research. 114 |
| ISSN: | 1872-8111 |
| Popis: | Accumulating evidence suggests that chronic inflammation plays a role in the progressive dopaminergic neurodegeneration that occurs in Parkinson's disease. It has been hypothesized that inflammation mediates neuronal damage via exacerbation of a vicious cycle of oxidative stress and mitochondrial dysfunction. The bacterial endotoxin, lipopolysaccharide (LPS), induces microglial activation and inflammation driven dopaminergic neurodegeneration. In order to test the hypothesis that LPS-induced inflammatory response might damage mitochondrial structure and function leading to nigral dopaminergic neuron loss, we injected LPS or saline into the striatum of rats. Here, we found that intrastriatal LPS induced deficit in mitochondrial respiration, damage to mitochondrial cristae, mitochondrial oxidation and nitration. Finally, we found significant loss of dopaminergic neurons in the substantia nigra one week after LPS injection. This study indicates that LPS-induced dopaminergic neurodegeneration might be exerted by mitochondrial injury. |
| Databáze: | OpenAIRE |
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