The Effect of Adding Dopamine Infusion to Noradrenaline Infusion Combined With Restrictive Hydration on Renal Function and Tissue Perfusion during Open Abdominal Surgeries
| Autor: | George M Nakhla, Rami M Wahba, Ayman Anis Metry, Fady A Abdelmalek, Milad Z Ragaei, Adham Feteha Tawfik |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_treatment
Group ii Renal function norepinephrine Norepinephrine (medication) 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine 030202 anesthesiology Dopamine restrictive hydration Materials Chemistry medicine Creatinine Creatinine level business.industry 030208 emergency & critical care medicine serum lactate standard hydration chemistry Anesthesia Original Article Serum lactate dopamine business Fluid replacement Perfusion medicine.drug |
| Zdroj: | Anesthesia, Essays and Researches |
| ISSN: | 2229-7685 0259-1162 |
| Popis: | Objectives: This study was designed to assess the effect of adding dopamine infusion in addition to restrictive hydration combined with noradrenaline infusion on intraoperative renal function and serum lactate levels in comparison to restrictive hydration combined with noradrenaline infusion only and standard hydration during open abdominal surgeries. Patients and Methods: One hundred and twenty patients were randomly assigned into three equal groups undergoing major open abdominal procedures. In Group I, dopamine infusion in addition to norepinephrine infusion were administered with restrictive hydration. In Group II, norepinephrine infusion was started before the induction of anesthesia with restrictive hydration. In Groups I and II, Ringer's solution was infused at a fixed rate of 2 mL.kg-1.h-1 until the end of surgery. In Group III, the conventional fluid replacement was introduced according maintenance, fluid deficit and third space loss. The outcome to be assessed was serial measurements of creatinine and serum lactate levels preoperatively, intraoperatively, and just postoperatively in addition to after 24 h. Results: Serum lactate level was significantly low in Groups I and II than that in Group III intraoperatively and postoperatively. In addition, urine output was significantly more in Group I and Group III than in Group II. Creatinine level was higher with significance in Group II than in Group I and III 24 h postoperatively. Conclusion: Dopamine infusion, when added to norepinephrine infusion combined with restricted hydration, improved urine output and creatinine level. Tissue perfusion as indicated by serum lactate level was more adequate in Groups I and II than that in Group III. |
| Databáze: | OpenAIRE |
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