Bullous pemphigoid with hyperkeratosis and palmoplantar keratoderma: Three cases
| Autor: | Valeria Pacifico, Dario Didona, Feliciana Mariotti, Biagio Didona, Naomi De Luca, Damiano Abeni, Cinzia Mazzanti, Luca Fania, Giovanni Di Zenzo |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Dystonin Biopsy Hyperkeratosis Dermatology Autoantigens 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Keratoderma Palmoplantar Pemphigoid Bullous medicine Humans In patient skin and connective tissue diseases Glucocorticoids Aged Autoantibodies Skin Biological Products integumentary system business.industry Autoantibody General Medicine Immunoglobulin E Middle Aged Non-Fibrillar Collagens medicine.disease eye diseases Palmoplantar keratoderma Female sense organs Bullous pemphigoid business 030215 immunology |
| Zdroj: | The Journal of Dermatology. 45:1135-1140 |
| ISSN: | 0385-2407 |
| Popis: | The clinical features of bullous pemphigoid are extremely polymorphous. Several atypical forms of bullous pemphigoid have been described, and the diagnosis critically relies on immunopathological findings. We describe three bullous pemphigoid patients characterized by palmoplantar keratoderma, diffused hyperkeratotic cutaneous lesions and extremely high levels of immunoglobulin E serum. The diagnosis of bullous pemphigoid should be taken into account in patients presenting diffused hyperkeratotic cutaneous lesions and palmoplantar keratoderma, even in the absence of blisters. Alteration of the keratinization process, that could occur in patients with genetic mutations in desmosomal and hemidesmosomal genes, may also be due to circulating autoantibodies against hemidesmosomal proteins in these bullous pemphigoid patients. |
| Databáze: | OpenAIRE |
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