Impact of Rotavirus Vaccine Introduction on Rotavirus Hospitalizations Among Children Under 5 Years of Age-World Health Organization African Region, 2008-2018
| Autor: | Jason M. Mwenda, Richard Mihigo, Ado Bwaka, Goitom Weldegebriel, Keith Shaba, Umesh D. Parashar, Gilson Kipese Paluku, Aboubacar N'diaye, Felicitas Zawaira, Jacqueline E. Tate, Isah Mohammed Bello, Benjamin D Hallowell, Bernard Ntsama, Joseph Nsiari-Muzeyi Biey |
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| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Adult Diarrhea Rotavirus medicine.medical_specialty medicine.disease_cause World Health Organization World health Rotavirus Infections medicine Humans Child business.industry Public health Rotavirus Vaccines Infant Acute gastroenteritis Vaccine introduction Rotavirus vaccine Confidence interval Hospitalization Infectious Diseases Child Preschool medicine.symptom business Demography |
| Zdroj: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 73(9) |
| ISSN: | 1537-6591 |
| Popis: | Background Rotavirus is the leading cause of acute gastroenteritis (AGE) among children worldwide. Prior to rotavirus vaccine introduction, over one third of AGE hospitalizations in Africa were due to rotavirus. We describe the impact of rotavirus vaccines using data from the African Rotavirus Surveillance Network (ARSN). Methods For descriptive analysis, we included all sites reporting to ARSN for any length of time between 2008 and 2018. For vaccine impact analysis, continuous surveillance throughout the year was required to minimize potential bias due to enrollment of partial seasons and sites had to report a minimum of 100 AGE cases per year. We report the proportion of rotavirus AGE cases by year relative to vaccine introduction, and the relative reduction in the proportion of rotavirus AGE cases reported following vaccine introduction. Results From 2008 to 2018, 97 366 prospectively enrolled hospitalized children Conclusions Rotavirus vaccine introduction led to large and consistent declines in the proportion of hospitalized AGE cases that are positive for rotavirus. To maximize the public health benefit of these vaccines, efforts to introduce rotavirus vaccines in the remaining countries in the region and to improve coverage should continue. |
| Databáze: | OpenAIRE |
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