Novel Method for the Covalent Immobilization of Oligonucleotides via Diels-Alder Bioconjugation

Autor:	Hallie A. Latham-Timmons, J. Shawn Roach, Rubina Giare, Andreas Wolter, Michael Leuck
Rok vydání:	2003
Předmět:	Aqueous solution Bioconjugation Diene Surface Properties Oligonucleotide Chemistry Organic Oligonucleotides General Medicine engineering.material Biochemistry chemistry.chemical_compound chemistry Coating Covalent bond Polymer chemistry Genetics engineering Molecular Medicine Surface modification Glass Oligonucleotide Probes Maleimide
Zdroj:	Nucleosides, Nucleotides and Nucleic Acids. 22:1495-1497
ISSN:	1532-2335 1525-7770
DOI:	10.1081/ncn-120023019
Popis:	The synthesis of cyclohexadiene and maleimide derivatives and their use for the functionalization of oligonucleotides and the coating of glass surfaces is reported. A method for the covalent attachment of diene or maleimide modified oligonucleotides to the coated glass surfaces via aqueous Diels-Alder reactions is presented.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2733028aeeecda5842b547263e27b78 https://doi.org/10.1081/ncn-120023019 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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