Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3,5-difluoro- 6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylglycine (ZK-807834): A Potent, Selective, and Orally Active Inhibitor of the Blood Coagulation Enzyme Factor Xa

Autor:	Joseph Post, Elena Ho, Amy Liang, Ron Vergona, Raju Mohan, Lan Trinh, Marc Whitlow, Janette Walters, Morrissey Michael M, Wei Xu, Josephine Hinchman, Sunil K. Koovakkat, David D. Davey, Gary Phillips, David R. Light, Brad O. Buckman, William J. Guilford, David J. Smith, Kathy White, Mark E. Sullivan, Keith Eagen, Shung Wu, Ng Howard P, Babu Subramanyam, Kenneth J. Shaw
Rok vydání:	1998
Předmět:	Models Molecular Serine Proteinase Inhibitors Molecular model Pyridines Stereochemistry Amidines Drug Evaluation Preclinical Molecular Conformation Administration Oral Biological Availability Crystallography X-Ray Benzylidene Compounds Chemical synthesis Amidine Structure-Activity Relationship chemistry.chemical_compound Dogs In vivo Drug Discovery Animals Humans chemistry.chemical_classification Binding Sites biology Thrombin Anticoagulants Stereoisomerism Macaca fascicularis Enzyme Coagulation chemistry Enzyme inhibitor Injections Intravenous biology.protein Molecular Medicine Cattle Trypsin Inhibitors Selectivity Factor Xa Inhibitors Papio
Zdroj:	Journal of Medicinal Chemistry. 41:3557-3562
ISSN:	1520-4804 0022-2623
DOI:	10.1021/jm980280h
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27239681e30eb87c628051c339a2324 https://doi.org/10.1021/jm980280h Zobrazit plný text záznamu