Eosinophilic asthma, according to a blood eosinophil criterion, is associated with disease severity and lack of control among underprivileged urban Brazilians
| Autor: | Namhee Kwon, Eduardo Vieira Ponte, Juliana Pires Viana de Jesus, Alvaro A. Cruz, Paula Cristina Andrade Almeida, Aline Lima-Matos, Luane Marques de Mello, Valmar Bião Lima, John H. Riley |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Spirometry medicine.medical_specialty Urban Population Severity of Illness Index Leukocyte Count 03 medical and health sciences 0302 clinical medicine immune system diseases Internal medicine Eosinophilic medicine Humans Eosinophilia 030212 general & internal medicine Pulmonary Eosinophilia Asthma medicine.diagnostic_test business.industry Case-control study Middle Aged Eosinophil Airway obstruction medicine.disease respiratory tract diseases Eosinophils medicine.anatomical_structure 030228 respiratory system Case-Control Studies Sputum Female medicine.symptom business Biomarkers Brazil |
| Zdroj: | Respiratory Medicine. 145:95-100 |
| ISSN: | 0954-6111 |
| Popis: | Background Asthma is a syndrome with multiple phenotypes. Peripheral blood eosinophil counts might be the ideal biomarker to identify subjects with eosinophilic asthma. It is available, inexpensive, and it is associated with eosinophilia in sputum. Objective The aim of this study was to evaluate whether blood eosinophilia is associated with asthma severity and to evaluate whether blood eosinophilia is associated with lack of control of asthma symptoms and airway obstruction. Methods Case control study. The cases were subjects recruited from a cohort of patients with severe asthma, in Salvador-BR, demanding continuous inhaled corticosteroids and LABA. There were two control groups: 1) subjects with mild/moderate asthma, 2) subjects with no asthma. Subjects enrolled in the study answered questionnaires, had their blood and stool samples collected, performed spirometry and SPT. We established a cutoff ≥ 260 cells/mm3 for blood eosinophilia. Results We evaluated 544 subjects in the case group, 452 subjects with mild to moderate asthma and 450 subjects with no asthma. The subjects of the case group had higher odds of presenting the eosinophilic phenotype in comparison to subjects with mild to moderate asthma [OR 1.60 95CI(1.19-2.16)] and no asthma [OR 3.93; 95CI(2.90-5.33)]. The eosinophilic phenotype, according to blood count, is associated with uncontrolled asthma [OR 1.56; 95CI(1.06-2.28)], but it is not associated with airway obstruction [OR 0.87; 95CI(0.61-1.24)]. Conclusion We conclude that the blood eosinophilia is a biomarker associated with asthma severity and poor symptom control, but we found no association with reduced lung function. |
| Databáze: | OpenAIRE |
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