A disinhibitory microcircuit for associative fear learning in the auditory cortex
| Autor: | Steffen B. E. Wolff, Andreas Lüthi, Johannes J. Letzkus, Cyril Herry, Julien Courtin, Elisabeth M. M. Meyer, Philip Tovote |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Nerve net Conditioning Classical Models Neurological Neural Inhibition Poison control Nicotinic Antagonists Receptors Nicotinic Optogenetics Stimulus (physiology) Auditory cortex Mice 03 medical and health sciences 0302 clinical medicine Interneurons Neural Pathways medicine Animals 030304 developmental biology Auditory Cortex Electroshock 0303 health sciences Multidisciplinary Pyramidal Cells Extremities Fear Mice Inbred C57BL medicine.anatomical_structure Disinhibition Synaptic plasticity Nerve Net medicine.symptom Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Nature |
| ISSN: | 1476-4687 0028-0836 |
| DOI: | 10.1038/nature10674 |
| Popis: | Learning causes a change in how information is processed by neuronal circuits. Whereas synaptic plasticity, an important cellular mechanism, has been studied in great detail, we know much less about how learning is implemented at the level of neuronal circuits and, in particular, how interactions between distinct types of neurons within local networks contribute to the process of learning. Here we show that acquisition of associative fear memories depends on the recruitment of a disinhibitory microcircuit in the mouse auditory cortex. Fear-conditioning-associated disinhibition in auditory cortex is driven by foot-shock-mediated cholinergic activation of layer 1 interneurons, in turn generating inhibition of layer 2/3 parvalbumin-positive interneurons. Importantly, pharmacological or optogenetic block of pyramidal neuron disinhibition abolishes fear learning. Together, these data demonstrate that stimulus convergence in the auditory cortex is necessary for associative fear learning to complex tones, define the circuit elements mediating this convergence and suggest that layer-1-mediated disinhibition is an important mechanism underlying learning and information processing in neocortical circuits. |
| Databáze: | OpenAIRE |
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