Collagen, Factor VIII Antigen, and Immunoglobulins in the Human Aqueous Drainage Channels
| Autor: | Jean-Michel Foidart, Merlyn M. Rodrigues, George Link Spaeth, Stephen I. Katz |
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| Rok vydání: | 1980 |
| Předmět: |
Male
Pathology medicine.medical_specialty genetic structures Open angle glaucoma medicine.medical_treatment Immunoglobulins Glaucoma Aqueous Humor Type IV collagen Antigen Trabecular Meshwork Laminin medicine Humans Trabeculectomy Antigens Aged Factor VIII biology Immunoperoxidase business.industry Complement C3 Middle Aged medicine.disease eye diseases Immunoglobulin A Microscopy Electron Ophthalmology medicine.anatomical_structure Immunoglobulin M Immunoglobulin G Immunology biology.protein Female Collagen sense organs Trabecular meshwork business |
| Zdroj: | Ophthalmology. 87:337-345 |
| ISSN: | 0161-6420 |
| DOI: | 10.1016/s0161-6420(80)35242-1 |
| Popis: | Twenty-five trabeculectomy specimens from patients with primary open angle glaucoma and chronic angle closure glaucoma, and 11 age-matched controls were examined by immunofluorescence and immunoperoxidase techniques to determine the types of collagen, immunoglobulins, and the presence of factor VIII-related antigen in the human aqueous drainage channels. In the glaucoma cases and in controls, we demonstrated that the electron dense basement membrane-like material in the peripheral portion of the trabecular beams and in the juxtacanalicular meshwork, consists at least in part, of type IV collagen, a noncollagenous protein ("laminin") and fibronectin. Factor VIII-related antigen was demonstrated in conjunctival vessels of the control eyes. Schlemm's canal and the trabecular endothelial cells did not stain for factor VIII-related/antigen in any of the specimens examined. No deposits of IgA, IgM, IgG, and the C3 component of complement were detected in the aqueous drainage channels. |
| Databáze: | OpenAIRE |
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