Current concepts in central nervous system regeneration
| Autor: | Ross D. Gurgo, Kuldip S. Bedi, Victor Nurcombe |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Central Nervous System
Regeneration (biology) Central nervous system General Medicine Biology Neural stem cell Nerve Regeneration Transplantation medicine.anatomical_structure Neurology Neurotrophic factors Central Nervous System Diseases Physiology (medical) medicine book.journal Animals Humans Surgery Neurology (clinical) Olfactory ensheathing glia Stem cell Developmental neurobiology book Neuroscience |
| Zdroj: | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 9(6) |
| ISSN: | 0967-5868 |
| Popis: | A dictum long-held has stated that the adult mammalian brain and spinal cord are not capable of regeneration after injury. Recent discoveries have, however, challenged this dogma. In particular, a more complete understanding of developmental neurobiology has provided an insight into possible ways in which neuronal regeneration in the central nervous system may be encouraged. Knowledge of the role of neurotrophic factors has provided one set of strategies which may be useful in enhancing CNS regeneration. These factors can now even be delivered to injury sites by transplantation of genetically modified cells. Another strategy showing great promise is the discovery and isolation of neural stem cells from adult CNS tissue. It may become possible to grow such cells in the laboratory and use these to replace injured or dead neurons. The biological and cellular basis of neural injury is of special importance to neurosurgery, particularly as therapeutic options to treat a variety of CNS diseases becomes greater. |
| Databáze: | OpenAIRE |
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