Congo Red as a Supramolecular Carrier System for Doxorubicin: An Approach to Understanding the Mechanism of Action

Autor:	Klaudia Kwiecińska, Anna Stachowicz-Kuśnierz, Beata Korchowiec, Maciej Roman, Wojciech M. Kwiatek, Anna Jagusiak, Irena Roterman, Jacek Korchowiec
Rok vydání:	2022
Předmět:	Excipients Inorganic Chemistry doxorubicin Langmuir films drug–membrane interactions Raman spectroscopy molecular dynamics simulations drug carrier Doxorubicin Organic Chemistry Congo Red General Medicine Physical and Theoretical Chemistry Hydrophobic and Hydrophilic Interactions Molecular Biology Spectroscopy Catalysis Computer Science Applications
Zdroj:	International Journal of Molecular Sciences; Volume 23; Issue 16; Pages: 8935
ISSN:	1422-0067
DOI:	10.3390/ijms23168935
Popis:	The uptake and distribution of doxorubicin in the MCF7 line of breast-cancer cells were monitored by Raman measurements. It was demonstrated that bioavailability of doxorubicin can be significantly enhanced by applying Congo red. To understand the mechanism of doxorubicin delivery by Congo red supramolecular carriers, additional monolayer measurements and molecular dynamics simulations on model membranes were undertaken. Acting as molecular scissors, Congo red particles cut doxorubicin aggregates and incorporated them into small-sized Congo red clusters. The mixed doxorubicin/Congo red clusters were adsorbed to the hydrophilic part of the model membrane. Such behavior promoted transfer through the membrane.
Databáze:	OpenAIRE
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