Liver Injury by the Traditional Chinese Medicine Hanshirento, Zenshikunshito, and Ninjin’yoeito in a Patient with Lung Cancer: Probable Causality Assessed by the Updated Roussel Uclaf Causality Assessment Method
| Autor: | Hitomi Ida, Hironori Sagara, Ayaka Kashima, Yoshito Miyata, Kenji Momo, Tadanori Sasaki, Haruki Funakoshi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
drug safety Lung Neoplasms Case Report Traditional Chinese medicine lcsh:RC254-282 03 medical and health sciences traditional Chinese medicine 0302 clinical medicine medicine cancer Humans zenshikunshito ninjin’yoeito Medicine Chinese Traditional Intensive care medicine Lung cancer Liver injury hanshirento business.industry Cancer saireito Middle Aged medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Causality 030205 complementary & alternative medicine Complementary and alternative medicine Oncology herb 030220 oncology & carcinogenesis Assessment methods Female RUCAM Chemical and Drug Induced Liver Injury business liver injury Drugs Chinese Herbal |
| Zdroj: | Integrative Cancer Therapies Integrative Cancer Therapies, Vol 20 (2021) |
| ISSN: | 1552-695X 1534-7354 |
| Popis: | Introduction: Traditional Chinese medicine (TCM) is a traditional treatment based on herbal medicines and holistic healing. It has resulted in both favorable and unfavorable patient outcomes when used to treat cancer. Cancer patients frequently depend on second opinions and folk remedies. In this case, we report the case of TCM inducing repeated moderate liver injury and delay for chemotherapy. Case presentation: A 59-year-old woman was diagnosed with lung cancer and conducted surgery a month ago. She went to a TCM specialty clinic expecting a complete cure for the lung cancer, to improve her physical condition, and to enhance her immunity. She received the TCM formulas hanshirento, zenshikunshito, and ninjin’yoeito. After starting these medicines, she felt severe fatigue but continued them for approximately 2 weeks, After discontinuing the medicine, her fatigue was improved. She was admitted to our hospital for adjuvant chemotherapy. On admission, laboratory tests revealed moderate liver injury (AST: 705 U/L, ALT: 1091 U/L). In view of her medication history, the laboratory tests, and her lifestyle history, we thought that moderate liver injury was caused by TCM, employing the Roussel Uclaf Causality Assessment Method (RUCAM). Discussion: TCM are known to be metabolized by the resident bacteria in the small intestine, but the specific metabolic processes are not well understood. Cancer patients sometimes try TCM from their own research to stay healthy. However, as with our case, TCM rarely induces liver injury, which is not well known to TCM users. Medical staffs need to be vigilant with their drug histories, including TCM, if patients have liver injuries. |
| Databáze: | OpenAIRE |
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