Adolescent risk taking, cocaine self-administration, and striatal dopamine signaling
| Autor: | Marci R. Mitchell, B. Sofia Beas, Jennifer L. Bizon, Virginia G. Weiss, Drake Morgan, Barry Setlow |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Quinpirole media_common.quotation_subject Dopamine Decision Making Poison control Self Administration Striatum Pharmacology Bioinformatics Risk-Taking Cocaine Dopamine Uptake Inhibitors Dopamine receptor D2 Injury prevention medicine Animals Rats Long-Evans RNA Messenger media_common Analysis of Variance Dose-Response Relationship Drug Receptors Dopamine D2 Age Factors Abstinence Corpus Striatum Rats Psychiatry and Mental health Animals Newborn Dopamine Agonists Conditioning Operant Original Article Analysis of variance Psychology Self-administration medicine.drug |
| Zdroj: | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 39(4) |
| ISSN: | 1740-634X |
| Popis: | Poor decision making and elevated risk taking, particularly during adolescence, have been strongly linked to drug use; however the causal relationships among these factors are not well understood. To address these relationships, a rat model (the Risky Decision-making Task; RDT) was used to determine whether individual differences in risk taking during adolescence predict later propensity for cocaine self-administration and/or whether cocaine self-administration causes alterations in risk taking. In addition, the RDT was used to determine how risk taking is modulated by dopamine signaling, particularly in the striatum. Results from these experiments indicated that greater risk taking during adolescence predicted greater intake of cocaine during acquisition of self-administration in adulthood, and that adult cocaine self-administration in turn caused elevated risk taking that was present following 6 weeks of abstinence. Greater adolescent risk taking was associated with lower striatal D2 receptor mRNA expression, and pharmacological activation of D2/3 receptors in the ventral, but not dorsal, striatum induced a decrease in risk taking. These findings indicate that the relationship between elevated risk taking and cocaine self-administration is bi-directional, and that low striatal D2 receptor expression may represent a predisposing factor for both maladaptive decision making and cocaine use. Furthermore, these findings suggest that striatal D2 receptors represent a therapeutic target for attenuating maladaptive decision making when choices include risk of adverse consequences. |
| Databáze: | OpenAIRE |
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