Curative Effect of Crude Exopolysaccharides of Some Macrofungi on Alcohol-induced Liver Damage

Autor:	Kazim Kartkaya, Mediha Canbek, Ozge Turgak, Hakan Senturk, Güngör Kanbak, Mustafa Yamaç, Mustafa Uyanoglu, Aysegul Oglakci
Rok vydání:	2013
Předmět:	Male Time Factors DNA Fragmentation Biology Protective Agents Pathology and Forensic Medicine Microbiology Rats Sprague-Dawley Andrology chemistry.chemical_compound Microscopy Electron Transmission Structural Biology Lactate dehydrogenase medicine Animals Liver Diseases Alcoholic Membrane Potential Mitochondrial Liver injury Mushroom Ethanol L-Lactate Dehydrogenase Caspase 3 Basidiomycota Alanine Transaminase Fungal Polysaccharides medicine.disease biology.organism_classification Rats Disease Models Animal medicine.anatomical_structure Liver Alanine transaminase chemistry Cytoprotection Hepatocyte biology.protein Coprinus comatus DNA fragmentation Bacterial outer membrane Biomarkers
Zdroj:	Ultrastructural Pathology. 37:218-226
ISSN:	1521-0758 0191-3123
DOI:	10.3109/01913123.2013.786297
Popis:	The authors investigate the curative effects of crude exopolysaccharides (EPS) produced by four Basidomycetes strains on the symptoms of alcoholic liver injury. EPSs were administered to experimental groups at levels of 100 mg per kg body weight per day for 7 days using an oral zonde needle after the onset of the disease. Serum levels of alanine transaminase (ALT), lactate dehydrogenase (LDH), DNA fragmentation, caspase-3 activities, and mitochondrial outer membrane integrity were determined following sacrifice of the rats. Light and transmission electron microscope (TEM) studies were performed on liver sections for histopathological and cytological evaluations. EPS that was obtained from Coprinus comatus OBCC 1014 decreased serum ALT level and increased outer membrane integrity, and allowed for the regaining of histologically and cytologically normal hepatocyte and tissue views. As a result, based on the obtained data, it can be argued that among all studied mushroom strains crude exopolysaccharides from Coprinus comatus OBCC 1014 strain have therapeutic potential for alcoholic liver injury according to control groups.
Databáze:	OpenAIRE
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