Evaluation of methemoglobin as an autologous intravascular MRI contrast agent
| Autor: | Claudia E. Kasserra, Peter Jezzard, Stefan Duewell, Robert S. Balaban |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Gadolinium DTPA
Pathology medicine.medical_specialty MRI contrast agent Contrast Media Kidney Methemoglobin Dogs Nuclear magnetic resonance Bolus (medicine) In vivo Image Processing Computer-Assisted Organometallic Compounds medicine Animals Radiology Nuclear Medicine and imaging 4-Aminopyridine Lagomorpha biology medicine.diagnostic_test Chemistry Magnetic resonance imaging Pentetic Acid biology.organism_classification Magnetic Resonance Imaging medicine.anatomical_structure Rabbits Perfusion |
| Zdroj: | Magnetic Resonance in Medicine. 35:787-789 |
| ISSN: | 1522-2594 0740-3194 |
| DOI: | 10.1002/mrm.1910350521 |
| Popis: | Methemoglobin (MetHb) was evaluated as an intravascular paramagnetic contrast agent. Methemoglobin formation was induced by 4-dimethylaminophenol (4-DMAP), causing a reduction in blood T2* in vitro. The 4-DMAP generated metHb with a time constant of 62 s. A 4-DMAP bolus did not decrease measurably the signal intensity in the in vivo rabbit kidney in the first pass. At steady state, a MetHb concentration of 24.8 +/- 2.3% resulted in a signal decrease of 9.2 +/- 2.6% in the kidney. Methemoglobin is an effective vascular T2* relaxation agent, but the formation of MetHb by 4-DMAP is too slow for first-pass imaging. A more effective conversion agent resulting in a bolus of at least 25% MetHb within 5 s would result in a detectable first-pass signal and a viable contrast technique. |
| Databáze: | OpenAIRE |
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