cPSA and fPSA elimination in African-American men
| Autor: | Carol D. Cheli, Maria Ward, Donald E. Mercante, Walter Rayford, B. J. Martin, D. Lifsey, M Kokatnur, R Davis |
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| Rok vydání: | 2003 |
| Předmět: |
Prostate adenocarcinoma
Adult Male Cancer Research medicine.medical_specialty Urology medicine.medical_treatment Adenocarcinoma White People Prostate cancer Reference Values Internal medicine medicine African american men Male population Humans Total protein Aged Prostatectomy business.industry Prostatic Neoplasms Middle Aged Prostate-Specific Antigen medicine.disease Black or African American Endocrinology Oncology business |
| Zdroj: | Prostate cancer and prostatic diseases. 6(2) |
| ISSN: | 1365-7852 |
| Popis: | In all, 22 African-American males undergoing radical prostatectomy for prostate adenocarcinoma had serum drawn for tPSA, cPSA, and total protein concentrations prior to, during, and after operation to determine the respective elimination rates. African-American cPSA was found to fit best a simple first-order exponential elimination kinetic, with a half-life of 44.6 h. fPSA followed a two-compartment elimination with an alpha-phase elimination of 0.50 h and a beta-phase half-life of 4.2 h. Our results suggest higher rates of elimination for both cPSA and fPSA in an African-American male population with respect to Caucasians and may account for differences in PSA values between races. |
| Databáze: | OpenAIRE |
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