Transdermal oestrogen replacement therapy in a Finnish population
| Autor: | M. Ryynänen, P. Sipilä, P. Holma, T. Virtavuo, T. Järvi, Reijo Punnonen, Olavi Ylikorkala, E. Tunkelo, S. Nummi, K. Rehn, A. Virkkunen, Risto Erkkola, T. Raudaskoski |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Chemotherapy
medicine.medical_specialty Oestrogen replacement therapy business.industry medicine.drug_class medicine.medical_treatment Estrogen Replacement Therapy Obstetrics and Gynecology Middle Aged Administration Cutaneous General Biochemistry Genetics and Molecular Biology Surgery Sauna bathing Finnish population Tolerability Estrogen Internal medicine medicine Humans Female business Depression (differential diagnoses) Transdermal |
| Zdroj: | Maturitas. 13:275-281 |
| ISSN: | 0378-5122 |
| DOI: | 10.1016/0378-5122(91)90236-j |
| Popis: | In an open, multicentre study, transdermal administration of oestradiol (E2) by means of skin patches was investigated in a Finnish patient population suffering from typical post-menopausal symptoms. A total of 249 women applied a patch twice weekly for 6 months. Whereas 85% of the subjects were experiencing hot flushes and 83.5% sweating before therapy, only 5.7% and 11.8%, respectively, reported these symptoms at the end of the trial. Furthermore, 97.6%, 95.7% and 94.8% of the subjects reported that depression, headache and sleep disturbances, respectively, had disappeared during therapy. Skin irritation occurred in 18.2% of these predominantly fair-skinned women. Frequent sauna bathing did not interfere with the patch therapy. General acceptance of the treatment was excellent, 84.8% of the patients completing the treatment, of whom 78% were willing to continue the treatment after the trial. These results show that transdermal administration of E2 is effective in relieving post-menopausal symptoms. Local tolerability was good and the majority of the patients considered the transdermal treatment to be superior to their previous oral replacement therapy. |
| Databáze: | OpenAIRE |
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