Prenatal maternal vitamin D deficiency sex-dependently programs adipose tissue metabolism and energy homeostasis in offspring

Autor: Eva M. Seipelt, Julien Astier, Béatrice Loriod, Jean-François Landrier, Hortense Vachon, Franck Tourniaire, Charlène Couturier, Lourdes Mounien, Michel Pucéat
Přispěvatelé: Lucas, Nelly, Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Theories and Approaches of Genomic Complexity (TAGC), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Transscriptomics and Genomics of Marseille-Luminy (TGML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Marseille medical genetics - Centre de génétique médicale de Marseille (MMG)
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
medicine.medical_specialty
Offspring
[SDV]Life Sciences [q-bio]
Adipose tissue
Context (language use)
vitamin D
Biology
maternal vitamin D deficiency
Biochemistry
Energy homeostasis
03 medical and health sciences
Mice
0302 clinical medicine
Sex Factors
Pregnancy
Internal medicine
Genetics
Vitamin D and neurology
medicine
Glucose homeostasis
Animals
Homeostasis
Molecular Biology
ComputingMilieux_MISCELLANEOUS
Adiposity
Fetus
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology
offspring
Estradiol
Body Weight
Micronutrient
Vitamin D Deficiency
Mice
Inbred C57BL
030104 developmental biology
Endocrinology
Glucose
Adipose Tissue
Prenatal Exposure Delayed Effects
Female
Energy Metabolism
metabolism
030217 neurology & neurosurgery
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Biotechnology
Zdroj: FASEB Journal
FASEB Journal, 2020, 34 (11), pp.14905-14919. ⟨10.1096/fj.201902924RR⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2020, 34 (11), pp.14905-14919. ⟨10.1096/fj.201902924RR⟩
ISSN: 1530-6860
0892-6638
DOI: 10.1096/fj.201902924RR⟩
Popis: International audience; In utero environment is crucial to ensure normal development of the fetus and to program metabolic health throughout the life. Beside macronutrients, the role of micronutrients, including vitamin D, begins to be explore. The aim of this study was to decipher the impact of maternal vitamin D deficiency (VDD), in normal and high‐fat (HF) diet context, on adipose tissue metabolism and energy homeostasis in offspring, considering sex‐specific responses. Body weight, energy expenditure, and spontaneous activity was differential impacted in juvenile male and female offspring born from VDD mice. In adulthood, a HF diet combined with maternal VDD disrupted glucose homeostasis and adiposity in male offspring but not in females. Such phenotypes were associated to different transcriptomic profiles in adipose tissue, which could be related to differential modulation of plasma 17β‐estradiol concentrations. Thus, maternal VDD sex‐dependently modulated metabolic fate of the offspring, especially when associated with HF diet in adulthood.
Databáze: OpenAIRE
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