Repolarisation and refractoriness during early ischaemia in humans
| Autor: | Ruben Coronel, P Taggart, Peter Morgan Sutton, R Trimlett, Tobias Opthof, P Kallis, W Pugsley |
|---|---|
| Přispěvatelé: | Faculteit der Geneeskunde, Other departments |
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Heart disease Refractory period Myocardial Ischemia Ischemia Diastole Action Potentials Coronary Disease Cardiovascular Medicine law.invention Coronary artery disease Ventricular Dysfunction Left law Internal medicine Cardiopulmonary bypass Humans Medicine Repolarization Aged Cardiopulmonary Bypass business.industry Cardiac Pacing Artificial Effective refractory period Middle Aged medicine.disease Editorial Cardiology Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Scopus-Elsevier Heart, 84, 365-369. BMJ Publishing Group Heart (British Cardiac Society), 84(4), 365-369. BMJ Publishing Group |
| ISSN: | 0007-0769 1355-6037 |
| DOI: | 10.1136/heart.84.4.365 |
| Popis: | OBJECTIVES—To determine whether effective refractory period (ERP) shortens or lengthens in the first minutes of ischaemia in humans, and the relation between ERP changes and action potential duration (APD). METHODS—ERP and monophasic action potential duration (MAPD) were measured from a single left ventricular epicardial site in 26 patients undergoing coronary artery surgery. Cardiopulmonary bypass was instituted and normothermia maintained. Refractory period was determined by the extrastimulus technique at a basic cycle length of 500 ms, at four times (group 1, 15 patients) or two times (group 2, 11 patients) the preischaemic diastolic threshold. A three minute period of ischaemia was instituted by aortic cross clamping between the input from the pump oxygenator and the heart. RESULTS—After three minutes of ischaemia, mean (SEM) ERP lengthened from 232 (5) ms (control) to 246 (7) ms (p |
| Databáze: | OpenAIRE |
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