Inhibition of BMP9 Induced Bone Formation by Salicylic-acid Polymer Capping
| Autor: | Kyungsup Shin, Jaidev L. Chakka, Liu Hong, Aliasger K. Salem, Timothy M. Acri, Noah Z. Laird, Satheesh Elangovan |
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| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Calvarial defect Materials science Mechanical Engineering Regeneration (biology) RNA Biomaterial 02 engineering and technology Polymer 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences Article 0104 chemical sciences chemistry.chemical_compound chemistry Mechanics of Materials parasitic diseases Biophysics General Materials Science Bone formation 0210 nano-technology Salicylic acid Increased bone formation |
| Zdroj: | MRS Adv |
| ISSN: | 2059-8521 |
| DOI: | 10.1557/adv.2020.61 |
| Popis: | This work focuses on the development of a system to control the formation of bone to complement developments that have enabled potent regeneration of bony tissue. Scaffolds were fabricated with chemically modified RNA encoding for bone morphogenetic protein-9 (cmBMP9) and capped with salicylic acid (SA)-containing polymer (SAPAE). The goal was to determine if SAPAE could inhibit the formation of bone in a pilot animal study since cmBMP9 has been demonstrated to be highly effective in regenerating bone in a rat calvarial defect model. The results indicated that cmBMP9 increased bone formation (30% increase in area covered compared to control) and that SAPAE trended toward reducing the bone formation. These results suggest SAPAE could be useful as a chemical agent in reducing unwanted bone formation in implants loaded with cmBMP9. |
| Databáze: | OpenAIRE |
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