Non-inherited maternal human leukocyte antigen alleles in susceptibility to familial rheumatoid arthritis
| Autor: | J L Nelson, N R Tishkevich, K A Guthrie |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Risk medicine.medical_specialty Adolescent Genotype Immunology Mothers Human leukocyte antigen Article General Biochemistry Genetics and Molecular Biology Arthritis Rheumatoid Sex Factors Rheumatology Internal medicine Immunopathology medicine Humans Immunology and Allergy Genetic Predisposition to Disease Age of Onset Allele Child Alleles Aged business.industry HLA-DR Antigens Middle Aged medicine.disease Histocompatibility Logistic Models Child Preschool Rheumatoid arthritis Female Age of onset business Epitope Mapping HLA-DRB1 Chains |
| Zdroj: | Annals of the Rheumatic Diseases. 68:107-109 |
| ISSN: | 1468-2060 0003-4967 |
| Popis: | Objectives:Some patients with rheumatoid arthritis (RA) lack RA-associated human leukocyte antigen (HLA) alleles. Prior studies investigated non-inherited maternal HLA alleles (NIMA) in RA risk with conflicting results.Methods:We examined NIMA in a large cohort of families from the North American Rheumatoid Arthritis Consortium (NARAC).Results:Among 620 patients with 1 or both parents having a HLA genotype, patients with RA informative for analysis included 176 without HLA-DRB1*04 and 86 without the HLA shared epitope (SE). The frequency of NIMA encoding HLA-DR4 or the SE was compared to the non-inherited paternal allele (NIPA). DR4-encoding NIMA vs NIPA revealed no significant difference (27% vs 20%). However, parity is known to modulate RA risk and analyses stratified by sex and age of onset showed significant variation among women. Interestingly, among women with onset Conclusions:Risk of RA was associated with HLA-DR4 encoding NIMA in younger-onset women but not in older-onset women or men. These observations could help explain conflicting prior results of NIMA in RA. |
| Databáze: | OpenAIRE |
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