Advances in Human B19 Erythrovirus Biology
| Autor: | Jean-Jacques Lefrère, Annabelle Servant-Delmas, Sylvie Pillet, Frédéric Morinet |
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| Rok vydání: | 2010 |
| Předmět: |
viruses
Immunology Apoptosis Virus Replication Microbiology Virus Parvoviridae Infections Virology Parvovirus B19 Human Humans Phylogeny Genetics Parvoviridae Molecular Epidemiology Erythrovirus biology Molecular epidemiology Mechanism (biology) Genetic Variation virus diseases Virus Internalization biology.organism_classification Human genetics Viral replication Insect Science Erythema Infectiosum Host-Pathogen Interactions Minireview |
| Zdroj: | Journal of Virology. 84:9658-9665 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.00684-10 |
| Popis: | Since its discovery, human parvovirus B19 (B19V), now termed erythrovirus, has been associated with many clinical situations (neurological and myocardium infections, persistent B19V DNAemia) in addition to the prototype clinical manifestations, i.e., erythema infectiosum and erythroblastopenia crisis. In 2002, the use of new molecular tools led to the characterization of three different genotypes of human B19 erythrovirus. Although the genomic organization is conserved, the geographic distribution of the different genotypes varies worldwide, and the nucleotidic divergences can impact the molecular diagnosis of B19 virus infection. The cell cycle of the virus remains partially unresolved; however, recent studies have shed light on the mechanism of cell entry and the interactions of B19V proteins with apoptosis pathways. |
| Databáze: | OpenAIRE |
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