A gelatin-thrombin matrix topical hemostatic agent (Floseal) in combination with harmonic scalpel is effective in patients undergoing total thyroidectomy: A prospective, multicenter, single-blind, randomized controlled trial
| Autor: | DOCIMO, Giovanni, TOLONE, SALVATORE, CONZO, Giovanni, LIMONGELLI, Paolo, DEL GENIO, Gianmattia, PARMEGGIANI, Domenico, DE PALMA M, LUPONE G, AVENIA N, LUCCHINI R, MONACELLI M, GULOTTA G, SCERRINO G, PASQUALI, Daniela, BELLASTELLA, Giuseppe, ESPOSITO, Katherine, DE BELLIS, Annamaria, PEZZOLLA A, RUGGIERO, Roberto, DOCIMO L. : A. Gelatin Thrombin Matrix Topical Hemostatic Agent in Combination With Harmonic Scalpel Is Effective in Patients Undergoing Total Thyroidectomy: A. Prospective, Multicenter, Single Blind, Randomized Controlled T.r.i.a.l. Surg I.n.n.o.v. 2015 Aug 3. pii: 1.5.5.3.3.5.0.6.1.5.5.9.6.6.3.8. [Epub ahead of print] PMID: 26243629 |
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| Přispěvatelé: | Docimo G., Tolone S., Conzo G., Limongelli P., Del Genio G., Parmeggiani D., De Palma M., Lupone G., Avenia N., Lucchini R., Monacelli M., Gulotta G., Scerrino G., Pasquali D., Bellastella G., Esposito K., De Bellis A., Pezzolla A., Ruggiero R., Docimo L., Docimo, Giovanni, Tolone, Salvatore, Conzo, Giovanni, Limongelli, Paolo, DEL GENIO, Gianmattia, Parmeggiani, Domenico, DE PALMA, M, Lupone, G, Avenia, N, Lucchini, R, Monacelli, M, Gulotta, G, Scerrino, G, Pasquali, Daniela, Bellastella, Giuseppe, Esposito, Katherine, DE BELLIS, Annamaria, Pezzolla, A, Ruggiero, Roberto, Docimo, Ludovico, Multicenter, Single, Blind, [Epub ahead of print] PMID: 26243629, Randomized Controlled T. r. i. a. l. Surg I. n. n. o. v. 2015 Aug 3. pii: 1. 5. 5. 3. 3. 5. 0. 6. 1. 5. 5. 9. 6. 6. 3. 8. |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty food.ingredient medicine.medical_treatment hemostatic agent 030230 surgery Gelatin Hemostatics law.invention 03 medical and health sciences Hemostatic 0302 clinical medicine food Thrombin Randomized controlled trial law Harmonic scalpel Humans Medicine Prospective Studies Prospective cohort study Floseal gelatin-thrombin matrix harmonic scalpel total thyroidectomy Hemostatic Agent business.industry Thyroidectomy Middle Aged Surgical Instruments Gelatin Sponge Absorbable Surgery Prospective Studie Treatment Outcome 030220 oncology & carcinogenesis Hemostasis Anesthesia Female business Human medicine.drug |
| Popis: | BACKGROUND: Hemostasis during thyroidectomy is essential; however, the safest, most efficient, and most cost-effective way to achieve this is unclear. This randomized, multicenter, single-blind, prospective study evaluated the efficacy and safety of using different hemostatic approaches in patients undergoing total thyroidectomy. METHODS: Patients aged ≥18 to 70 years were randomized to Floseal + a harmonic scalpel (HS), Floseal alone, HS alone, or standard total thyroidectomy. Primary endpoint was 24-hour drain output. Secondary endpoints included surgery duration and complications. RESULTS: Two hundred and six patients were randomized to Floseal + HS (n = 52), Floseal alone (n = 54), HS alone (n = 50), and standard total thyroidectomy (n = 50). The 24-hour drain output was lower in the Floseal + HS group compared with standard thyroidectomy. Floseal + HS also had a shorter surgery time (P < .0001) versus the other 3 treatments. CONCLUSION: Floseal + HS can be effective at reducing postsurgical drain output and provides a complementary hemostatic approach in patients undergoing total thyroidectomy. © The Author(s) 2015. Background. Hemostasis during thyroidectomy is essential; however, the safest, most efficient, and most cost-effective way to achieve this is unclear. This randomized, multicenter, single-blind, prospective study evaluated the efficacy and safety of using different hemostatic approaches in patients undergoing total thyroidectomy. Methods. Patients aged ≥18 to 70 years were randomized to Floseal + a harmonic scalpel (HS), Floseal alone, HS alone, or standard total thyroidectomy. Primary endpoint was 24-hour drain output. Secondary endpoints included surgery duration and complications. Results. Two hundred and six patients were randomized to Floseal + HS (n = 52), Floseal alone (n = 54), HS alone (n = 50), and standard total thyroidectomy (n = 50). The 24-hour drain output was lower in the Floseal + HS group compared with standard thyroidectomy. Floseal + HS also had a shorter surgery time (P |
| Databáze: | OpenAIRE |
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