Transfusing platelets 2 h after the completion of amphotericin‐B decreases its detrimental effect on transfused platelet recovery and survival
| Autor: | B J Bolwell, A Hoeltge, R Fletcher, K Zuccaro, M A Hussein, T J Long |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Blood Platelets
medicine.medical_specialty Antifungal Agents Time Factors Cell Survival medicine.medical_treatment Platelet Transfusion Bone Marrow Aplasia Drug Administration Schedule Immunocompromised Host Amphotericin B Neoplasms Humans Medicine Platelet Mean platelet volume Prospective cohort study Bone Marrow Transplantation Retrospective Studies Chemotherapy Platelet Count business.industry Graft Survival Retrospective cohort study Hematology Thrombocytopenia Surgery Platelet transfusion Mycoses Anesthesia business medicine.drug |
| Zdroj: | Transfusion Medicine. 8:43-47 |
| ISSN: | 1365-3148 0958-7578 |
| Popis: | Platelet transfusion support is required during bone marrow aplasia following ablative chemotherapy and bone marrow progenitor cell transplantation (BMT). Amphotericin-B is frequently given to these patients, both therapeutically and prophylactically, and has been described to have a negative impact on the results of platelet transfusions. We conducted a prospective study of the effect of amphotericin-B on transfused platelet recovery and survival in 81 BMT or acute leukaemia patients. One hundred and ninety-five platelet transfusions administered to 81 consecutive patients were analysed. The platelets were transfused 2 h after the completion of amphotericin-B. Using this schedule resulted in no effect of amphotericin-B on platelet recovery or survival, although platelet increments were modestly depressed in patients receiving high- vs. low-dose amphotericin-B. We conclude that the timing of amphotericin-B infusion be evaluated in patients demonstrating poor platelet recovery and survival. Transfusing platelets at least 2 h after the completion of amphotericin-B decreases the detrimental effect of this antifungal agent on transfused platelet recovery and survival. |
| Databáze: | OpenAIRE |
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