Comparative efficacy of lithium and amitriptyline in the maintenance treatment of recurrent unipolar depression: a randomised study
| Autor: | J. Tegeler, G.A.E. Rudolf, B. Müller-Oerlinghausen, T. Wetterling, Rolf R. Engel, Henner Giedke, Natalia Erazo, A. Czernik, Heinrich Sauer, Waldemar Greil, Michael Osterheider, W. Ludwig-Mayerhofer |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Lithium (medication) Amitriptyline medicine.medical_treatment Antidepressive Agents Tricyclic Lithium law.invention chemistry.chemical_compound Randomized controlled trial Antimanic Agents Recurrence law Internal medicine medicine Humans Depression (differential diagnoses) Aged Subclinical infection Depressive Disorder Chemotherapy Dose-Response Relationship Drug Lithium carbonate Middle Aged Long-Term Care Surgery Psychiatry and Mental health Clinical Psychology Treatment Outcome chemistry Concomitant Female Psychology Follow-Up Studies medicine.drug |
| Zdroj: | Journal of Affective Disorders. 40:179-190 |
| ISSN: | 0165-0327 |
| DOI: | 10.1016/0165-0327(96)00070-5 |
| Popis: | The present study, including 81 depressive patients, compares the prophylactic efficacy of lithium and amitriptyline in recurrent unipolar depression over a treatment period of 2.5 years in a randomised multicentre design. Hospitalisation, re-emergence of depressive or subdepressive recurrences, unwanted side-effects and need of concomitant psychotropic medication were considered to indicate treatment failures. Average dosage for amitriptyline was 98 +/- 37 mg/day, average lithium blood level was 0.59 +/- 0.12 mmol/l. Survival analyses demonstrated a significant superiority of lithium (P = 0.015) regarding the outcome criteria 'recurrences and/or subclinical recurrences' and non-significantly better results of lithium compared to amitriptyline concerning 'recurrence' (P = 0.059) or 'recurrence and/or concomitant medication' (P = 0.066). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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