A population-specific diabetogenic haplotype HLA-A2,Cw1,B56,DR4,DQ8 is associated with high birthweight in Finnish diabetic families
| Autor: | Eva Tuomilehto-Wolf, Valma Harjutsalo, Tiina M. Järvinen, Maija E. Miettinen, Leena Kinnunen, J. Tuomilehto |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Genotype endocrine system diseases Offspring Immunology Physiology 030209 endocrinology & metabolism Human leukocyte antigen Biology Childhood obesity 03 medical and health sciences Sex Factors 0302 clinical medicine HLA-A2 Antigen Genetics medicine Birth Weight Humans Genetic Predisposition to Disease Finland reproductive and urinary physiology Genetics (clinical) 030304 developmental biology 0303 health sciences Type 1 diabetes Haplotype Infant Newborn nutritional and metabolic diseases medicine.disease Obesity 3. Good health Diabetes Mellitus Type 1 Haplotypes Linear Models Female medicine.symptom Weight gain Maternal Age |
| Zdroj: | Genes & Immunity. 9:207-213 |
| ISSN: | 1476-5470 1466-4879 |
| Popis: | Children with type 1 diabetes (T1D) susceptibility HLA genotypes are shown to have an increased birthweight. We investigated to what extent T1D-predisposing HLA haplotypes were associated with increased birthweight. A total of 1255 Finnish children comprising those with T1D and their non-diabetic siblings were investigated. A total of 342 children and their non-diabetic parents were HLA genotyped. Birthweight data were obtained from the national Medical Birth Registry. The population-specific diabetogenic haplotype HLA-A2,Cw1,B56,DR4,DQ8 was associated with high birthweight (P=0.0280) in families with a diabetic offspring. Other T1D-predisposing HLA haplotypes showed nonsignificant tendency with high birthweight. More infants with a birthweightor=4000 g were born in families with a T1D offspring than in the general Finnish population (P=0.0139). The previously observed direct association between birthweight and T1D risk may be mediated through the modulating effects that T1D susceptibility HLA genes have on weight. High birthweight and subsequent weight gain may accelerate the ongoing pancreatic autoimmune process in genetically susceptible individuals. The high proportion of infants having a birthweightor=4000 g in families with a diabetic offspring raises a concern of potential adverse health outcomes that high birthweight can have. |
| Databáze: | OpenAIRE |
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