Bloodstream Infections Caused by Carbapenemase-Producing Klebsiella pneumoniae Among Intensive Care Unit Patients After Orthotopic Liver Transplantation: Risk Factors for Infection and Impact of Resistance on Outcomes
| Autor: | E. Massa, S. Papadopoulos, V. Papanikolaou, M. Piperidou, A. Orphanou, T. Theodoridou, M. Passakiotou, G. Imvrios, Ioannis Fouzas, Elias Iosifidis, Ioannis Roilides, E. Mouloudi, N. Gritsi-Gerogianni |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Bacteremia Drug resistance Liver transplantation beta-Lactamases law.invention Liver disease Postoperative Complications Bacterial Proteins Risk Factors law Intensive care Internal medicine Drug Resistance Bacterial Humans Medicine Intensive care medicine Aged Retrospective Studies Transplantation Univariate analysis Greece APACHE II business.industry Incidence Retrospective cohort study Middle Aged medicine.disease Intensive care unit Anti-Bacterial Agents Klebsiella Infections Liver Transplantation Survival Rate Intensive Care Units Klebsiella pneumoniae Female Surgery business Follow-Up Studies |
| Zdroj: | Transplantation Proceedings. 46:3216-3218 |
| ISSN: | 0041-1345 |
| DOI: | 10.1016/j.transproceed.2014.09.159 |
| Popis: | Background Carbapenem-resistant Klebsiella pneumoniae (CRKP) has emerged as an important cause of bloodstream infections in intensive care units (ICUs). The aim of this study was to determine risk factors for bloodstream infections caused by CRKP as well as risk factors for CRKP-associated mortality among ICU patients after orthotopic liver transplantation (LT). Methods The study cohort of this observational study comprised 17 ICU patients after LT with CRKP bloodstream infections. The data from these patients were matched with 34 ICU patients (1:2) after LT without CRKP infections. The 2 groups were compared to identify risk factors for development of CRKP infection and risk factors for mortality. Results Seventeen CRKP bloodstream infections occurred in ICU patients after LT from January 1, 2008, to December 31, 2011. In univariate analysis, primary liver disease and especially hepatitis C virus infection or hepatocellular cancer were significant factors for development of CRKP. Acute Physiology and Chronic Health Evaluation (APACHE II) score and Sequential Organ Failure Assessment (SOFA) score as well as CRKP bloodstream infection were predictors for ICU death (P Conclusions CRKP bloodstream infections affect immunocompromised post-transplantation patients more. Bloodstream infections with CRKP along with APACHE and SOFA scores were predictors of death in ICU patients after LT. |
| Databáze: | OpenAIRE |
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