Effects of high voltage pulsed current stimulation with a visible contraction intensity on expression of TGF-β1 and synthesis of type I collagen in wound-induced white rats
| Autor: | Jae-Keun Jeon, Joon-Hee Lee, Seung-Kyu Park |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Contraction (grammar) High voltage pulsed current stimulation business.industry Transforming growth factor β1 Wound Group ii Physical Therapy Sports Therapy and Rehabilitation Stimulation Surgery Endocrinology Internal medicine medicine Original Article Wound induced Wound healing business Type I collagen Transforming growth factor |
| Zdroj: | Journal of Physical Therapy Science |
| ISSN: | 2187-5626 0915-5287 |
| DOI: | 10.1589/jpts.27.1485 |
| Popis: | [Purpose] This study aimed to examine the expression of transforming growth factor β1 (TGF-β1) and type I collagen by applying high voltage pulsed current stimulation (HVPCS) with a visible contraction intensity to white rats with induced wounds. [Subjects] Thirty-six white rats were used for this study. HVPCS with a non-visible contraction intensity was applied to experimental group I, and HVPCS with a visible contraction intensity was applied to experimental group II. Placebo stimulation was applied to the control group. [Methods] After wounds were triggered, the intervention appropriate for each group was applied. Changes in the size of their wounds and expression of TGF- β1 and type I collagen were measured on the third, fifth, and seventh days. [Results] Comparison of the sizes of the wounds among the groups showed that the most significant decreases were found in experimental group II on the fifth and seventh days. TGF-β1 expression comparison revealed that experimental group II had the most expression on the fifth day. [Conclusion] HVPCS with a visible contraction intensity was effective in promoting wound healing by increasing expression of TGF-β1 and synthesis of type I collagen. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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