Maternal and neonatal phytoestrogens in Japanese women during birth
| Autor: | Shaw Watanabe, Teiichi Yamada, Kristiina Wähälä, Herman Adlercreutz |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Amniotic fluid Genistein Phytoestrogens Lignans chemistry.chemical_compound Isoflavonoid Asian People Japan Pregnancy Internal medicine Blood plasma medicine Humans Estrogens Non-Steroidal Prospective Studies Maternal-Fetal Exchange Fetus biology business.industry Infant Newborn Obstetrics and Gynecology biology.organism_classification medicine.disease Delivery Obstetric Fetal Blood Isoflavones Endocrinology chemistry Tasa Female Plant Preparations business |
| Zdroj: | American journal of obstetrics and gynecology. 180(3 Pt 1) |
| ISSN: | 0002-9378 |
| Popis: | Objective: High levels of soy isoflavonoids among adult Japanese persons are associated with a low incidence of hormone-dependent cancers, but nothing is known about isoflavonoids in pregnancy. Study Design: We studied 7 young healthy Japanese women at delivery by measuring 6 phytoestrogen metabolites in maternal and cord plasma and in amniotic fluid. Results: Total maternal plasma isoflavonoid concentrations ranged from 19 to 744 nmol/L (mean 232 nmol/L), cord plasma values ranged from 58 to 831 nmol/L (mean 299 nmol/L), and amniotic fluid values ranged from 52 to 779 nmol/L (mean 223 nmol/L). Maternal and cord plasma and amniotic fluid lignan values were low. Conclusions: The high levels of isoflavonoid phytoestrogens found in healthy neonatal Japanese infants indicate transfer of isoflavonoids from the maternal to the fetal compartment. These compounds may modify estrogen metabolism and action during fetal life and perhaps affect cancer risk. (Am J Obstet Gynecol 1999;180:737-43.) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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