Functional Correlation Between the Pancreas and the Small Intestine in Humans
| Autor: | Yoshiki Hirooka, Hiroki Kawashima, Manabu Kawai, Masatoshi Ishigami, Takuya Ishikawa, Kohei Funasaka, Takamichi Kuwahara, Osamu Watanabe, Ryoji Miyahara, Eizaburo Ohno, Masanao Nakamura, Hidemi Goto, Takeshi Yamamura, Daijuro Hayashi, Kazuhiro Furukawa, Senju Hashimoto |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Enteroscopy medicine.medical_specialty Endocrinology Diabetes and Metabolism Nutritional Status Incretin Gastric Inhibitory Polypeptide Gastroenterology Endoscopy Gastrointestinal Jejunum Islets of Langerhans 03 medical and health sciences 0302 clinical medicine Endocrinology Gastric inhibitory polypeptide Glucagon-Like Peptide 1 Internal medicine Diabetes mellitus Intestine Small Biopsy Internal Medicine medicine Humans Intestinal Mucosa Pancreas Aged Hepatology medicine.diagnostic_test business.industry Middle Aged medicine.disease Pancreas Exocrine Small intestine medicine.anatomical_structure 030220 oncology & carcinogenesis Female 030211 gastroenterology & hepatology business |
| Zdroj: | Pancreas. 47:601-608 |
| ISSN: | 1536-4828 0885-3177 |
| DOI: | 10.1097/mpa.0000000000001039 |
| Popis: | OBJECTIVES The aim of this study is to evaluate a functional correlation between the pancreas and the small intestine and the association of this relationship with nutritional status, using magnifying enteroscopy. METHODS The subjects were adults aged 20 years or older who underwent upper gastrointestinal endoscopy. An endoscope was inserted into the jejunum, and 10% glucose was sprayed under magnifying observation to evaluate changes in blood flow in the villous capillary network. Mucosal biopsy was performed before and after spraying to evaluate the incretin response in the jejunal mucosa. RESULTS A total of 124 patients participated in the study. There was a positive correlation between villous blood flow change and exocrine pancreas function (R = 0.4337, P < 0.0001). Changes of gastric inhibitory polypeptide and glucagon-like peptide messenger RNAs in biopsy samples were positively correlated with endocrine pancreas function in 88 patients without treatment for diabetes (R = 0.4314, P = 0.0012; R = 0.4112, P = 0.0081). In patients with lower villous blood flow change and decreased pancreatic exocrine function, the prognostic nutritional index were significantly lower (P = 0.0098), compared with other patients. CONCLUSIONS This study provides the first evidence of a close functional correlation between the pancreas and the small intestine. |
| Databáze: | OpenAIRE |
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