Placental IGF-1 and IGFBP-3 expression correlate with umbilical cord blood PAH and PBDE levels from prenatal exposure to electronic waste
| Autor: | Xijin Xu, Xia Huo, Yuangping Wang, Fangfang Lu, Taofeek A. Yekeen, Qiongna Xiao |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Placenta Health Toxicology and Mutagenesis Toxicology Electronic waste recycling Umbilical cord Electronic Waste Andrology Polybrominated diphenyl ethers Pregnancy Halogenated Diphenyl Ethers Fetal growth medicine Humans RNA Messenger Insulin-Like Growth Factor I Polycyclic Aromatic Hydrocarbons Prenatal exposure Fetus Chemistry General Medicine Fetal Blood Pollution Insulin-Like Growth Factor Binding Protein 3 medicine.anatomical_structure Mrna level Maternal Exposure Environmental chemistry Gestation Environmental Pollutants Female Environmental Monitoring |
| Zdroj: | Environmental Pollution. 182:63-69 |
| ISSN: | 0269-7491 |
| DOI: | 10.1016/j.envpol.2013.07.005 |
| Popis: | Electronic waste recycling produces Polycyclic Aromatic Hydrocarbons (PAHs) and Polybrominated Diphenyl Ethers (PBDEs) which may affect fetal growth and development by altering the insulin-like-growth factor (IGF) system. Questionnaires were administered to pregnant women (Guiyu, an e-waste site, n = 101; control, n = 53), and umbilical cord blood (UCB) and placentas were collected upon delivery. PBDEs and PAHs in UCB and placental IGF-1 and IGFBP-3 mRNA levels were analyzed using GC-MS and real-time PCR, respectively. Infant birth length and Apgar scores were lower in Guiyu. All PAHs (except Fl, Chr, IP, BbF and BP), total 16-PAHs, total/individual PBDEs, placental IGF-1 (median 0.23 vs 0.19; P < 0.05) and IGFBP-3 (median 1.91 vs 0.68; P < 0.001) levels were significantly higher in Guiyu. Spearman correlation showed that BDE-154, BDE-209 and ∑5ring-PAHs positively correlate with IGF-1 while PBDEs, 4 rings and total PAHs correlate with IGFBP-3 expression. Increased placental IGF-1 level might indirectly affect fetal growth and development. |
| Databáze: | OpenAIRE |
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