Rat protein tyrosine phosphatase eta physically interacts with the PDZ domains of syntenin
| Autor: | Rodolfo Iuliano, Ilaria Le Pera, Lorenzo Chiariotti, Giuseppe Viglietto, Francesca Lembo, Alfredo Fusco, Massimo Santoro, Francesco Trapasso, Marialuisa Martelli, Irene Samà |
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| Přispěvatelé: | Iuliano, R, Trapasso, F, Samà, I, Le Pera, I, Martelli, Ml, Lembo, Francesca, Santoro, Massimo, Viglietto, G, Chiariotti, Lorenzo, Fusco, Alfredo |
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
Syntenins
PDZ domain Biophysics Protein tyrosine phosphatase Biochemistry Insert (molecular biology) Syndecan 1 phosphatase Structural Biology oncogenesis Two-Hybrid System Techniques Complementary DNA Genetics Humans Molecular Biology Cells Cultured Malignant phenotype Thyroid Chemistry Receptor-Like Protein Tyrosine Phosphatases Class 3 Intracellular Signaling Peptides and Proteins Membrane Proteins Cell Biology Precipitin Tests Yeast Protein Structure Tertiary Tyrosine phosphatase Syntenin Protein Tyrosine Phosphatases Carrier Proteins Rat Protein |
| Zdroj: | FEBS letters 500 (2001): 41–44. info:cnr-pdr/source/autori:Iuliano R. 1, Trapasso F. 1, Sama I. 1, Le Pera I. 1, Martelli M.L. 1, Lembo F. 2, Santoro M. 2, Viglietto G. 2, Chiariotti L. 1, Fusco A. 1-2/titolo:Rat protein tyrosine phosphatase eta physically interacts with the PDZ domains of syntenin./doi:/rivista:FEBS letters (Print)/anno:2001/pagina_da:41/pagina_a:44/intervallo_pagine:41–44/volume:500 |
| Popis: | The tyrosine phosphatase r-PTPeta is able to suppress the malignant phenotype of rat thyroid tumorigenic cell lines. To identify r-PTPeta interacting proteins, a yeast two-hybrid screening was performed and an insert corresponding to the full-length syntenin cDNA was isolated. It encodes a protein containing two PDZ domains that mediates the binding of syntenin to proteins such as syndecan, proTGF-alpha, beta-ephrins and neurofascin. We show that r-PTPeta is able to interact with syntenin also in mammalian cells, and although syntenin is a tyrosine-phosphorylated protein it is not a substrate of r-PTPeta. The integrity of both PDZ domains of syntenin and the carboxy-terminal region of r-PTPeta are required for the interaction between syntenin and r-PTPeta. |
| Databáze: | OpenAIRE |
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