Effect of Afobazole and Betaine on Cognitive Disorders in the Offspring of Rats with Streptozotocin-Induced Diabetes and Their Relationship with DNA Damage
| Autor: | Andrey D. Durnev, O. V. Shreder, V. V. Zabrodina, E. D. Shreder |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Offspring DNA damage Morpholines education Biology General Biochemistry Genetics and Molecular Biology Diabetes Mellitus Experimental 03 medical and health sciences chemistry.chemical_compound Cognition 0302 clinical medicine Betaine Pregnancy Placenta Internal medicine Diabetes mellitus medicine Animals General Medicine medicine.disease Streptozotocin Rats Comet assay 030104 developmental biology Endocrinology medicine.anatomical_structure Biochemistry chemistry Benzimidazoles Female Comet Assay Cognition Disorders 030217 neurology & neurosurgery DNA Damage medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 161:359-366 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | Cognitive activity in 60-day-old offspring of rats (intrauterine development in experimental streptozotocin-induced diabetes) was studied on the model of food-seeking behavior under conditions of free choice in a 6-arm maze. The formation of the food-procuring skill was significantly delayed, which attests to impairment of cognitive functions in these animals. Peroral administration of afobazole (10 and 50 mg/kg) and betaine (50 and 100 mg/kg) significantly and dose-dependently alleviated this disorder. Correlation analysis of the data on delayed formation of a food-procuring skill and results of DNA comet attests to a strong relationship between DNA damage in cells of the embryo and placenta during intrauterine development and cognitive dysfunction in the postnatal offspring of animals with streptozotocin-induced diabetes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink