Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19
| Autor: | Qin Liu, David S.C. Hui, Siew C. Ng, Gavin M. Joynt, Terry Cheuk-Fung Yip, Fen Zhang, Kai Ming Chow, Timothy Li, Amy Li, Chun K. Wong, Kitty S. C. Fung, Paul K.S. Chan, Tao Zuo, Arthur C.K. Chung, Chun Pan Cheung, Yun Kit Yeoh, Grace Lai-Hung Wong, Eugene Y.K. Tso, Francis K.L. Chan, Rita W Y Ng, Veronica L. Chan, Susanna So Shan Ng, Grace Lui, Lowell Ling |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult DNA Bacterial Male Inflammation Disease Gut flora Severity of Illness Index Virus Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Immune system Transferases Medicine Humans Microbiome biology Bacteria business.industry SARS-CoV-2 Gastroenterology Immunity COVID-19 medicine.disease biology.organism_classification Gastrointestinal Microbiome Gastrointestinal Tract 030104 developmental biology C-Reactive Protein Immunology Cytokines Dysbiosis Hong Kong 030211 gastroenterology & hepatology Female medicine.symptom business |
| Zdroj: | Gut |
| ISSN: | 1468-3288 |
| Popis: | ObjectiveAlthough COVID-19 is primarily a respiratory illness, there is mounting evidence suggesting that the GI tract is involved in this disease. We investigated whether the gut microbiome is linked to disease severity in patients with COVID-19, and whether perturbations in microbiome composition, if any, resolve with clearance of the SARS-CoV-2 virus.MethodsIn this two-hospital cohort study, we obtained blood, stool and patient records from 100 patients with laboratory-confirmed SARS-CoV-2 infection. Serial stool samples were collected from 27 of the 100 patients up to 30 days after clearance of SARS-CoV-2. Gut microbiome compositions were characterised by shotgun sequencing total DNA extracted from stools. Concentrations of inflammatory cytokines and blood markers were measured from plasma.ResultsGut microbiome composition was significantly altered in patients with COVID-19 compared with non-COVID-19 individuals irrespective of whether patients had received medication (pFaecalibacterium prausnitzii, Eubacterium rectale and bifidobacteria were underrepresented in patients and remained low in samples collected up to 30 days after disease resolution. Moreover, this perturbed composition exhibited stratification with disease severity concordant with elevated concentrations of inflammatory cytokines and blood markers such as C reactive protein, lactate dehydrogenase, aspartate aminotransferase and gamma-glutamyl transferase.ConclusionAssociations between gut microbiota composition, levels of cytokines and inflammatory markers in patients with COVID-19 suggest that the gut microbiome is involved in the magnitude of COVID-19 severity possibly via modulating host immune responses. Furthermore, the gut microbiota dysbiosis after disease resolution could contribute to persistent symptoms, highlighting a need to understand how gut microorganisms are involved in inflammation and COVID-19. |
| Databáze: | OpenAIRE |
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