Thromboembolic Events in Beta Thalassemia Major: An Italian Multicenter Study
| Autor: | C. Melevendi, F. Dore, Donatella Mattia, C. Borgna Pignatti, A Mangiagli, A. Di Palma, Vittorio Carnelli, G Pizzarelli, Maria Antonietta Romeo, Salvatore Musumeci, F. Di Gregorio, R. Longhi, Vincenzo Caruso |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Hemolytic anemia Pediatrics medicine.medical_specialty Adolescent endocrine system diseases Pregnancy Thromboembolism Diabetes mellitus Epidemiology medicine Humans Child Blood Coagulation business.industry Vascular disease Incidence (epidemiology) Pregnancy Complications Hematologic beta-Thalassemia Infant Newborn Hematology General Medicine medicine.disease Surgery Hemoglobinopathy Female Complication business |
| Zdroj: | Acta Haematologica. 99:76-79 |
| ISSN: | 1421-9662 0001-5792 |
| DOI: | 10.1159/000040814 |
| Popis: | Thromboembolic (TE) events have been frequently reported in β-thalassemic patients in association with known risk factors such as diabetes, complex cardiopulmonary abnormalities, hypothyroidism, liver function anomalies, and postsplenectomy thrombocytosis. In a recent survey involving 9 Italian thalassemic centers, we identified 32 patients with TE episodes in a total of 735 subjects, of whom 683 had thalassemia major and 52 thalassemia intermedia, corresponding to 3.95 and 9.61%, respectively. There was a great variation in localization: the main one (16/32) was CNS, with a clinical picture of headache, seizures and hemiparesis. Other localizations were the pulmonary (3 patients), mesenteric (1 patient) and portal (2 patients) sites. There were 6 cases of deep venous thrombosis (2 in the upper limbs, 4 in the lower ones). Intracardiac thrombosis was found in 2 subjects and clinical and laboratory signs of DIC were observed in 2 others during pregnancy. Since our patients with TE events present a statistically significantly higher incidence of associated dysfunction (cardiomyopathy, diabetes, liver function anomalies, hypothyroidism) than those without TE events (50 vs. 13.8%), we suggest close monitoring of those patients who are at higher risk of developing TE events because of the presence of one or more of these predisposing factors. |
| Databáze: | OpenAIRE |
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