Aldehyde dehydrogenase 1A1: friend or foe to female metabolism?

Autor: Jennifer M. Petrosino, David DiSilvestro, Ouliana Ziouzenkova
Rok vydání: 2013
Předmět:
Retinal dehydrogenase
Retinoic acid
Raldh
Aldehyde dehydrogenase
Adipose tissue
Review
chemistry.chemical_compound
Risk Factors
android obesity
Adipocytes
PCOS
Body Fat Distribution
lymphotactin
Nutrition and Dietetics
Adipogenesis
biology
Estradiol
Esr1
alcohol dehydrogenase
Thermogenesis
3. Good health
Cell biology
gender differences
Retinaldehyde
Cytokines
Female
lcsh:Nutrition. Foods and food supply
Polycystic Ovary Syndrome
medicine.medical_specialty
retinoids
Adipose Tissue
White
lcsh:TX341-641
Tretinoin
Aldehyde Dehydrogenase 1 Family
ALDH1A2
Sex Factors
Internal medicine
medicine
Animals
Humans
Obesity
Retinal Dehydrogenase
Aldehyde Dehydrogenase
tissue factor
Diet
ALDH1A1
Disease Models
Animal
Endocrinology
chemistry
Chronic Disease
biology.protein
oestrogen
Estrogen receptor alpha
Food Science
Zdroj: Nutrients
Nutrients, Vol 6, Iss 3, Pp 950-973 (2014)
ISSN: 2072-6643
Popis: In this review, we summarize recent advances in understanding vitamin A-dependent regulation of sex-specific differences in metabolic diseases, inflammation, and certain cancers. We focus on the characterization of the aldehyde dehydrogenase-1 family of enzymes (ALDH1A1, ALDH1A2, ALDH1A3) that catalyze conversion of retinaldehyde to retinoic acid. Additionally, we propose a “horizontal transfer of signaling” from estrogen to retinoids through the action of ALDH1A1. Although estrogen does not directly influence expression of Aldh1a1, it has the ability to suppress Aldh1a2 and Aldh1a3, thereby establishing a female-specific mechanism for retinoic acid generation in target tissues. ALDH1A1 regulates adipogenesis, abdominal fat formation, glucose tolerance, and suppression of thermogenesis in adipocytes; in B cells, ALDH1A1 plays a protective role by inducing oncogene suppressors Rara and Pparg. Considering the conflicting responses of Aldh1a1 in a multitude of physiological processes, only tissue-specific regulation of Aldh1a1 can result in therapeutic effects. We have shown through successful implantation of tissue-specific Aldh1a1−/− preadipocytes that thermogenesis can be induced in wild-type adipose tissues to resolve diet-induced visceral obesity in females. We will briefly discuss the emerging role of ALDH1A1 in multiple myeloma, the regulation of reproduction, and immune responses, and conclude by discussing the role of ALDH1A1 in future therapeutic applications.
Databáze: OpenAIRE
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