Brain-wide Mapping of Mono-synaptic Afferents to Different Cell Types in the Laterodorsal Tegmentum
| Autor: | Hongbin Yang, Fan Meng, Shumin Duan, Huifang Lou, Xiaomeng Wang, Ying Shen, Libiao Pan, Yi-Jun Liu, Sijia Hao, Xiaotong Wu, Hao Wang, Li Zhan |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Physiology Tegmentum Mesencephali Thalamus Sensory system Mice Transgenic Biology Periaqueductal gray Midbrain 03 medical and health sciences Mice 0302 clinical medicine medicine Animals Afferent Pathways Brain Mapping General Neuroscience Superior colliculus Optical Imaging General Medicine Limbic lobe Retrograde tracing Ventral tegmental area Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure nervous system Synapses Original Article Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neurosci Bull |
| ISSN: | 1995-8218 |
| Popis: | The laterodorsal tegmentum (LDT) is a brain structure involved in distinct behaviors including arousal, reward, and innate fear. How environmental stimuli and top-down control from high-order sensory and limbic cortical areas converge and coordinate in this region to modulate diverse behavioral outputs remains unclear. Using a modified rabies virus, we applied monosynaptic retrograde tracing to the whole brain to examine the LDT cell type specific upstream nuclei. The LDT received very strong midbrain and hindbrain afferents and moderate cortical and hypothalamic innervation but weak connections to the thalamus. The main projection neurons from cortical areas were restricted to the limbic lobe, including the ventral orbital cortex (VO), prelimbic, and cingulate cortices. Although different cell populations received qualitatively similar inputs, primarily via afferents from the periaqueductal gray area, superior colliculus, and the LDT itself, parvalbumin-positive (PV(+)) GABAergic cells received preferential projections from local LDT neurons. With regard to the different subtypes of GABAergic cells, a considerable number of nuclei, including those of the ventral tegmental area, central amygdaloid nucleus, and VO, made significantly greater inputs to somatostatin-positive cells than to PV(+) cells. Diverse inputs to the LDT on a system-wide level were revealed. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12264-019-00397-2) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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