| Autor: |
Zheng‐Ian Lin, Han‐Lin Tsai, Guan‐Lin Liu, Xie‐Hong Lu, Pei‐Wen Cheng, Pei‐Ling Chi, Chih‐Kuang Wang, Tzu‐Hsien Tsai, Chih‐Chia Wang, Jason Hsiao Chun Yang, Bao‐Tsan Ko, Chih‐Kuang Chen |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Macromolecular bioscience. 22(10) |
| ISSN: |
1616-5195 |
| Popis: |
Utilizing COsub2/subas one of the monomer resources, poly(vinylcyclohexene carbonates) (PVCHCs) are used as the precursor for preparing cationic PVCHCs (CPVCHCs) via thiol-ene click functionalization. Through the functionalization, CPVCHC-43 with a tertiary amine density of 43% relative to the backbone is able to display a significantly antibacterial ability against Staphylococcus aureus (S. aureus). Blending CPVCHC-43 with polyacrylonitrile (PAN), CPVCHC/PAN nanofiber meshes (NFMs) have been successfully prepared by electrospinning. More importantly, two crucial fibrous structural factors including CPVCHC/PAN weight ratio and fiber diameter have been systematically investigated for the effects on the antibacterial performance of the NFMs. Sequentially, a quaternization treatment has been employed on the NFMs with an optimal fibrous structure to enhance the antibacterial ability. The resulting quaternized NFMs have demonstrated the great biocidal effects against Gram-positive and Gram-negative bacteria. Moreover, the excellent biocompatibility of the quaternized NFMs have also been thoroughly evaluated and verified. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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