Aerobic Exercise Training and Nontraditional Cardiovascular Risk Factors in Hemodialysis Patients: Results from a Prospective Randomized Trial
| Autor: | João Carlos Hueb, Viviana Rugolo Oliveira e Silva, Roberto Jorge da Silva Franco, Luis Cuadrado Martin, Pasqual Barretti, Jacqueline Costa Teixeira Caramori, Fernanda Stringuetta Belik, Renato de Souza Gonçalves, Barbara Perez Vogt, Silméia Garcia Zanati Bazan, Greicy Mara Mengue Feniman De Stefano |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp) |
| Rok vydání: | 2019 |
| Předmět: |
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medicine.medical_specialty Urology medicine.medical_treatment 030232 urology & nephrology 030204 cardiovascular system & hematology Left ventricular hypertrophy law.invention 03 medical and health sciences Vascular Stiffness 0302 clinical medicine Randomized controlled trial Renal Dialysis Risk Factors law Chronic kidney disease Internal medicine medicine Humans Aerobic exercise Prospective Studies Exercise Sedentary lifestyle Intention-to-treat analysis Physical activity business.industry Middle Aged medicine.disease Exercise Therapy Vasodilation Cardiovascular diseases Cardiovascular Diseases Arterial stiffness Kidney Failure Chronic Female Hypertrophy Left Ventricular Endothelium Vascular Hemodialysis Cardiology and Cardiovascular Medicine business Kidney disease |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 1664-5502 1664-3828 |
| Popis: | Made available in DSpace on 2020-12-12T01:42:03Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-11-01 Introduction: Chronic kidney disease (CKD) patients have a high incidence of cardiovascular diseases (CVD) which increases their morbidity and mortality. A sedentary lifestyle in CKD is directly linked to the onset of CVD. Physical activity can bring beneficial effects to CKD patients. Aims: The aim of this study was assess the impact of aerobic training on nontraditional cardiovascular risk factors in CKD patients on hemodialysis. Materials and Methods: This is a prospective, controlled, and randomized clinical trial with analysis of intention to treat. Thirty patients underwent an exercise treadmill test, an arterial stiffness evaluation, echocardiography and analysis of endothelial reactivity, and carotid ultrasound and laboratorial tests, including analysis of serum aldosterone. The intervention group (IG) (n =15) underwent aerobic exercise during hemodialysis 3 times a week for 4 months. The control group (CG) (n =15) had no intervention. All of the patients were reassessed after 4 months. Results: In the IG, there was a statistically significant improvement in flow-mediated vasodilation (FMV; p = 0.002) and a reduction in left ventricular hypertrophy (p = 0.006) and serum aldosterone (p = 0.016). There was an increase in C-reactive protein in the CG (p = 0.002). Conclusion: This aerobic training protocol was able to improve endothelial function with enhanced FMV and reduce left ventricular hypertrophy and serum aldosterone, which could have a positive impact on the reduction of nontraditional cardiovascular risk factors in CKD patients on hemodialysis. Division of Nephrology Department of Internal Medicine Botucatu Medical School São Paulo State University (UNESP) Division of Cardiology Department of Internal Medicine Botucatu Medical School São Paulo State University (UNESP) Division of Nephrology Department of Internal Medicine Botucatu Medical School São Paulo State University (UNESP) Division of Cardiology Department of Internal Medicine Botucatu Medical School São Paulo State University (UNESP) |
| Databáze: | OpenAIRE |
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