Umbilical Cord Blood Leptin and IL-6 in the Presence of Maternal Diabetes or Chorioamnionitis
| Autor: | Lauren K. Vasilakos, Baiba Steinbrekera, Donna A. Santillan, Mark K. Santillan, Debra S. Brandt, Daniel Dagle, Robert D. Roghair |
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| Rok vydání: | 2021 |
| Předmět: |
Leptin
insulin obesity Interleukin-6 Endocrinology Diabetes and Metabolism digestive oral and skin physiology Infant Newborn Infant RC648-665 Fetal Blood Diseases of the endocrine glands. Clinical endocrinology neonatal sepsis Diabetes Gestational Chorioamnionitis inflammation Pregnancy Humans Female development hormones hormone substitutes and hormone antagonists |
| Zdroj: | Frontiers in Endocrinology, Vol 13 (2022) |
| ISSN: | 1664-2392 |
| Popis: | Diabetes during pregnancy is associated with elevated maternal insulin, leptin and IL-6. Within the placenta, IL-6 can further stimulate leptin production. Despite structural similarities and shared roles in inflammation, leptin and IL-6 have contrasting effects on neurodevelopment, and the relative importance of maternal diabetes or chorioamnionitis on fetal hormone exposure has not been defined. We hypothesized that there would be a positive correlation between IL-6 and leptin with progressively increased levels in pregnancies complicated by maternal diabetes and chorioamnionitis. To test this hypothesis, cord blood samples were obtained from 104 term infants, including 47 exposed to maternal diabetes. Leptin, insulin, and IL-6 were quantified by multiplex assay. Factors independently associated with hormone levels were identified by univariate and multivariate linear regression. Unlike IL-6, leptin and insulin were significantly increased by maternal diabetes. Maternal BMI and birth weight were independent predictors of leptin and insulin with birth weight the strongest predictor of leptin. Clinically diagnosed chorioamnionitis and neonatal sepsis were associated with increased IL-6 but not leptin. Among appropriate for gestational age infants without sepsis, IL-6 and leptin were strongly correlated (R=0.6, P |
| Databáze: | OpenAIRE |
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