Islet Microvasculature Alterations With Loss of Beta-cells in Patients With Type 1 Diabetes
| Autor: | Mark A. Atkinson, Martha Campbell-Thompson, Elizabeth A. Butterworth, Lith H. Nasif, Joseph S. Canzano, DongTao Fu |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine endocrine system medicine.medical_specialty Histology Adolescent endocrine system diseases Endothelium medicine.medical_treatment Fluorescent Antibody Technique 030209 endocrinology & metabolism Glucagon Alpha cell Islets of Langerhans Young Adult 03 medical and health sciences 0302 clinical medicine Insulin-Secreting Cells Diabetes mellitus Internal medicine medicine Humans Insulin Child Type 1 diabetes geography Microscopy Confocal geography.geographical_feature_category business.industry Articles medicine.disease Islet Actins Tissue Donors Transplantation Diabetes Mellitus Type 1 030104 developmental biology Endocrinology medicine.anatomical_structure Microvessels Female Anatomy business |
| Zdroj: | Journal of Histochemistry & Cytochemistry. 67:41-52 |
| ISSN: | 1551-5044 0022-1554 |
| DOI: | 10.1369/0022155418778546 |
| Popis: | Islet microvasculature provides key architectural and functional roles, yet the morphological features of islets from patients with type 1 diabetes are poorly defined. We examined islet and exocrine microvasculature networks by multiplex immunofluorescence imaging of pancreases from organ donors with and without type 1 diabetes ( n=17 and n=16, respectively) and determined vessel diameter, density, and area. We also analyzed these variables in insulin-positive and insulin-negative islets of 7 type 1 diabetes donors. Control islet vessel diameter was significantly larger (7.6 ± 1.1 μm) compared with vessels in diabetic islets (6.2 ± 0.8 μm; p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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