A new access to 4 H-quinolizines from 2-vinylpyridine and alkynes promoted by rhodium-N-heterocyclic-carbene catalysts
| Autor: | Jesús J. Pérez-Torrente, Ricardo Castarlenas, Andrea Di Giuseppe, Ramón Azpíroz, Luis A. Oro |
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| Přispěvatelé: | Ministerio de Economía y Competitividad (España), Diputación General de Aragón, ARAID Foundation |
| Rok vydání: | 2013 |
| Předmět: |
2-Vinylpyridine
Pyridines C-C coupling C-H activation carbenes electrocyclization quinolizine Alkynes Catalysis Coordination Complexes Methane Quinolizines Rhodium Stereoisomerism Electrocyclization chemistry.chemical_element Medicinal chemistry Coupling reaction chemistry.chemical_compound Organic chemistry Heterocycle formation Chemistry Organic Chemistry Quinolizine General Chemistry Carbenes Carbene |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | Forging the lock that autolocks! Rh-NHC catalysts promote a new access to 4 H-quinolizine species from 2-vinylpyridine and terminal and internal alkynes through C-H activation and C-C coupling reactions (see figure). N-Bridgehead heterocycle formation is favored for internal- over terminal-substituted butadienylpyridine derivatives in a thermal 6π-electrocyclization process. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Financial support from the Ministerio de Economía y Competitividad of Spain Project CTQ2010–15221), the Diputación General de Aragón (E07), the ARAID Foundation under the program “Jóvenes Investigadores”, and CONSOLIDER INGENIO-2010, under the Project MULTICAT (CSD2009–00050) are gratefully acknowledged. |
| Databáze: | OpenAIRE |
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