Water Thermodynamics and Its Effects on the Protein Stability and Activity
| Autor: | Sow-Hsin Chen, Paola Lanzafame, Domenico Mallamace, Georgia Papanikolaou, Francesco Mallamace |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Self-diffusion
Materials science relaxation times QH301-705.5 Crossover water Thermodynamics Decoupling (cosmology) self-diffusion Hydrophobic effect local order Molecular dynamics Viscosity Order (biology) protein folding Computer Science::Programming Languages General Earth and Planetary Sciences Protein folding Biology (General) hydrophobic effect General Environmental Science |
| Zdroj: | Biophysica Volume 1 Issue 4 Pages 30-428 Biophysica, Vol 1, Iss 30, Pp 413-428 (2021) |
| ISSN: | 2673-4125 |
| DOI: | 10.3390/biophysica1040030 |
| Popis: | We discuss a phenomenon regarding water that was until recently a subject of scientific interest: i.e., the dynamical crossover, from the fragile to strong glass forming material, for both bulk and protein hydration water. Such crossover is characterized by a temperature TL in which significant dynamical changes like the decoupling (or the violation of the Stokes-Einstein relation) of homologous transport parameters, e.g., the density relaxation time τ and the viscosity η, occur in the system. On this respect we considered the dynamic properties of water-protein systems. More precisely, we focused our study on proteins and their hydration water, as far as bulk and confined water. In order to clarify the effects of the water dynamical crossover on the protein properties we considered and discussed in a comparative way previous and new experimental data, obtained from different techniques and molecular dynamic simulation (MD). We pointed out the reasons for different dynamical findings from the use of different experimental techniques. |
| Databáze: | OpenAIRE |
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