The ALERT-B questionnaire: A screening tool for the detection of gastroenterological late effects after radiotherapy for prostate cancer
| Autor: | S.E. Taylor, Annmarie Nelson, S.H. Campbell, John Green, Damian J. J. Farnell, Stephanie Sivell, C.J. Ferguson, Ann Muls, John Staffurth, David S Sanders, R. O'Shea, S. Ahmedzai, Sara Pickett, J. Andreyev |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Cancer therapy R895-920 Article 030218 nuclear medicine & medical imaging 03 medical and health sciences Prostate cancer Medical physics. Medical radiology. Nuclear medicine 0302 clinical medicine Rating scale Internal medicine medicine Gastroenterological late effects Radiology Nuclear Medicine and imaging Screening tool ROC analysis RC254-282 Radiotherapy business.industry Curve analysis Neoplasms. Tumors. Oncology. Including cancer and carcinogens Baseline data medicine.disease Radiation therapy Oncology 030220 oncology & carcinogenesis Radiological weapon business |
| Zdroj: | Clinical and Translational Radiation Oncology, Vol 21, Iss, Pp 98-103 (2020) Clinical and Translational Radiation Oncology |
| ISSN: | 2405-6308 |
| Popis: | Highlights • ALERT-B provides an effective screening tool for gastroenterological late effects. • 84.4% and 95.7% of patients demonstrated complications at 6 and 12 months post-treatment. • ROC curves at baseline indicated an AUC of 0.867 compared to the GSRS diarrhoea subscale. • ROC curves at baseline indicated an AUC of 0.765 compared to the EPIC bowel subscale. There is an increasing need to measure treatment-related side effects in normal tissues following cancer therapy. The ALERT-B (Assessment of Late Effects of RadioTherapy - Bowel) questionnaire is a screening tool that is composed of four items related specifically to bowel symptoms. Those patients that respond with a “yes” to any of these items are referred on to gastroenterologist in order to improve the long-term consequences of these side effects of radiological treatment. Here we wish to test the ability of this questionnaire to identify these subsequent gastroenterological complications by tracking prostate cancer patients that were positive with respect to ALERT-B. We also carry out receiver-operator curve (ROC) analysis for baseline data for an overall ALERT-B questionnaire score with respect to subscale data for the Gastrointestinal Symptom Rating Scale (GSRS) and the Expanded Prostate Cancer Index Composite (EPIC-26) questionnaire. 84.4% and 95.7% of patients identified by the ALERT-B questionnaire demonstrated complications diagnosed at 6 and 12 months post-treatment, respectively. ROC curve analysis of baseline data showed that ALERT-B detected clinically relevant levels of side effects established at baseline by the GSRS diarrhoea subscale (AUC = 0.867, 95% CI = 0.795 to 0.926) and at the minimally important level of side effects for the EPIC bowel subscale (AUC = 0.765, 95% CI = 0.617 to 0.913). These results show that ALERT-B provides a simple and effective screening tool for identifying gastroenterological complications after treatment for prostate cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|