Genomewide DNA methylation dynamics upon diesel exhaust exposure in asthmatics
| Autor: | Michael S. Kobor, Ruiwei Jiang, Christopher Carlsten, Francesco Sava |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Pulmonary and Respiratory Medicine
Pathophysiology of asthma Innate immune system Diesel exhaust business.industry General Medicine Bioinformatics medicine.disease_cause Meeting Abstract DNA methylation Immunology Gene expression medicine Immunology and Allergy Epigenetics business Gene Oxidative stress |
| Zdroj: | Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology |
| ISSN: | 1710-1492 |
| DOI: | 10.1186/1710-1492-10-s1-a67 |
| Popis: | Background Particulate air pollution can induce epigenetic changes and regulate gene expression relevant to the pathophysiology of asthma and allergic diseases. Recently, epidemiologic data suggests that there are observable acute effects of air pollution on peripheral blood DNA methylation levels of genomewide Alu and LINE-1 repeat elements, as well as certain genes involved in oxidative stress response and innate immunity. In this study, we hypothesized that in a controlled exposure setting, diesel exhaust (as a model of |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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